肺炎球菌转化与突变中的标志物鉴别
Marker discrimination in transformation and mutation of pneumococcus.
作者信息
Tiraby J G, Fox M S
出版信息
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3541-5. doi: 10.1073/pnas.70.12.3541.
Abstract
Earlier investigations of pneumococcal transformation revealed a function (hex(+)) responsible for severely reducing the transformation yield of certain markers. A mutational alteration (hex(-)) responsible for the loss of this function has been transferred into a hex(+) strain to permit a comparison of the hex(+) and hex(-) phenotypes in an isogenic background. The loss of the hex(+) function results both in a loss of the capacity to eliminate the low efficiency markers in transformation and a substantial increase in the spontaneous mutation rate. These properties of the hex(-) strain could result from the loss of a capacity to eliminate certain classes of mismatched base pairs that occur as intermediates in both transformation and mutagenesis.
摘要
早期对肺炎球菌转化的研究揭示了一种功能（hex(+)），该功能会严重降低某些标记物的转化效率。一种导致该功能丧失的突变改变（hex(-)）已被转入hex(+)菌株，以便在同基因背景下比较hex(+)和hex(-)的表型。hex(+)功能的丧失既导致在转化中消除低效标记物的能力丧失，也导致自发突变率大幅增加。hex(-)菌株的这些特性可能是由于消除某些作为转化和诱变中间体出现的错配碱基对的能力丧失所致。
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