过氧化物在吞噬杀灭肺炎球菌中的作用。
Role of peroxide in phagocytic killing of pneumococci.
作者信息
Pitt J, Bernheimer H P
出版信息
Infect Immun. 1974 Jan;9(1):48-52. doi: 10.1128/iai.9.1.48-52.1974.
Abstract
Two mutants of a pneumococcus type I with diminished peroxide production were selected from a population of nitrosoguanidine-treated cells. White cells of normal patients killed the mutant pneumococci as well as the otherwise isogenic wild-type strain. In patients studied with chronic granulomatous disease, however, the peroxide-poor strain was killed far less well than the wild type. These studies indicate that the removal of a peroxide-generating system in the phagocytic vacuole specifically brings forth the killing defect in chronic granulomatous disease.
摘要
从经亚硝基胍处理的肺炎链球菌I型菌群体中筛选出两个过氧化物产生减少的突变体。正常患者的白细胞对突变型肺炎球菌以及其他方面同基因的野生型菌株的杀伤效果相同。然而，在患有慢性肉芽肿病的患者中，过氧化物产生较少的菌株被杀伤的程度远低于野生型。这些研究表明，吞噬泡中过氧化物生成系统的缺失特异性地导致了慢性肉芽肿病中的杀伤缺陷。
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