大肠杆菌K-12中三种天冬氨酸激酶和两种高丝氨酸脱氢酶结构基因的定位
Mapping of the structural genes of the three aspartokinases and of the two homoserine dehydrogenases of Escherichia coli K-12.
作者信息
Thèze J, Margarita D, Cohen G N, Borne F, Patte J C
出版信息
J Bacteriol. 1974 Jan;117(1):133-43. doi: 10.1128/jb.117.1.133-143.1974.
Abstract
Mutants requiring threonine plus methionine (or homoserine), or threonine plus methionine plus diaminopimelate (or homoserine plus diaminopimelate) have been isolated from strains possessing only one of the three isofunctional aspartokinases. They have been classified in several groups according to their enzymatic defects. Their mapping is described. Several regions of the chromosome are concerned: thrA (aspartokinase I-homoserine dehydrogenase I) is mapped in the same region as thrB and thrC (0 min). lysC (aspartokinase III) is mapped at 80 min, far from the other genes coding for diaminopimelate synthesis. metLM (aspartokinase II-homoserine dehydrogenase II) lies at 78 min closely linked to metB, metJ, and metF.
摘要
已从仅具有三种同功天冬氨酸激酶之一的菌株中分离出需要苏氨酸加蛋氨酸（或高丝氨酸），或苏氨酸加蛋氨酸加二氨基庚二酸（或高丝氨酸加二氨基庚二酸）的突变体。根据它们的酶缺陷，已将它们分为几组。描述了它们的定位。染色体的几个区域涉及其中：thrA（天冬氨酸激酶I-高丝氨酸脱氢酶I）与thrB和thrC定位在同一区域（0分钟）。lysC（天冬氨酸激酶III）定位在80分钟处，远离其他编码二氨基庚二酸合成的基因。metLM（天冬氨酸激酶II-高丝氨酸脱氢酶II）位于78分钟处，与metB、metJ和metF紧密连锁。
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