大肠杆菌K-12中天冬氨酸半醛脱氢酶的多价抑制作用
Multivalent repression of aspartic semialdehyde dehydrogenase in Escherichia coli K-12.
作者信息
Boy E, Patte J C
出版信息
J Bacteriol. 1972 Oct;112(1):84-92. doi: 10.1128/jb.112.1.84-92.1972.
Abstract
Mutants of Escherichia coli in which the lysine-sensitive aspartokinase is feedback-resistant are described. In these strains, as well as in the wild type, aspartic semialdehyde dehydrogenase is subject to multivalent repression by lysine, threonine, and methionine. When these amino acids were added to a culture in minimal medium, the differential rate of synthesis of the enzyme dropped to zero and remained there for about one generation.
摘要
本文描述了赖氨酸敏感天冬氨酸激酶具有反馈抗性的大肠杆菌突变体。在这些菌株以及野生型菌株中，天冬氨酸半醛脱氢酶受到赖氨酸、苏氨酸和蛋氨酸的多价阻遏。当将这些氨基酸添加到基本培养基中的培养物中时，该酶的合成差异速率降至零，并在那里保持约一代时间。
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