长期给予苯巴比妥及其撤药后对大鼠肝脏色氨酸吡咯酶活性的影响以及它们与乙醇作用的相似性。
The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.
作者信息
Badawy A A, Evans M
出版信息
Biochem J. 1973 Nov;135(3):555-7. doi: 10.1042/bj1350555.
Abstract
Chronic phenobarbitone administration inhibits the apo-(tryptophan pyrrolase) activity in homogenates of rat liver and subsequent withdrawal enhances the enzyme activity by 2.5-fold. Similar effects have been previously produced by chronic ethanol administration and withdrawal, but, whereas NADH may cause the ethanol inhibition, that by phenobarbitone may be mediated by NADPH.
摘要
长期给予苯巴比妥会抑制大鼠肝脏匀浆中脱辅基（色氨酸吡咯酶）的活性，随后停药会使该酶活性增强2.5倍。慢性给予乙醇并随后停药此前也产生过类似效果，但是，虽然还原型辅酶Ⅰ（NADH）可能导致乙醇抑制作用，但苯巴比妥的抑制作用可能由还原型辅酶Ⅱ（NADPH）介导。
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