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长期给予苯巴比妥及其撤药后对大鼠肝脏色氨酸吡咯酶活性的影响以及它们与乙醇作用的相似性。

The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.

作者信息

Badawy A A, Evans M

出版信息

Biochem J. 1973 Nov;135(3):555-7. doi: 10.1042/bj1350555.

DOI:10.1042/bj1350555
PMID:4149247
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1165861/
Abstract

Chronic phenobarbitone administration inhibits the apo-(tryptophan pyrrolase) activity in homogenates of rat liver and subsequent withdrawal enhances the enzyme activity by 2.5-fold. Similar effects have been previously produced by chronic ethanol administration and withdrawal, but, whereas NADH may cause the ethanol inhibition, that by phenobarbitone may be mediated by NADPH.

摘要

长期给予苯巴比妥会抑制大鼠肝脏匀浆中脱辅基（色氨酸吡咯酶）的活性，随后停药会使该酶活性增强2.5倍。慢性给予乙醇并随后停药此前也产生过类似效果，但是，虽然还原型辅酶Ⅰ（NADH）可能导致乙醇抑制作用，但苯巴比妥的抑制作用可能由还原型辅酶Ⅱ（NADPH）介导。

相似文献

1
The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.长期给予苯巴比妥及其撤药后对大鼠肝脏色氨酸吡咯酶活性的影响以及它们与乙醇作用的相似性。
Biochem J. 1973 Nov;135(3):555-7. doi: 10.1042/bj1350555.
2
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Biochem J. 1975 Jun;148(3):425-32. doi: 10.1042/bj1480425.

本文引用的文献

1
A microsomal iron-porphyrin activator of rat liver tryptophan pyrrolase.大鼠肝脏色氨酸吡咯酶的微粒体铁卟啉激活剂。
J Biol Chem. 1961 Jan;236:153-7.
2
The effects of salicylate on the activity of rat liver tryptophan pyrrolase in vitro and in vivo.水杨酸盐对大鼠肝脏色氨酸吡咯酶体内外活性的影响。
Biochem J. 1971 Jun;123(2):171-4. doi: 10.1042/bj1230171.
3
The relationship between delta-aminolaevulinate synthetase induction and the concentration of cytochrome P-450 and catalase in rat liver.大鼠肝脏中δ-氨基乙酰丙酸合成酶诱导与细胞色素P-450及过氧化氢酶浓度之间的关系。
Biochem J. 1972 Apr;127(3):553-9. doi: 10.1042/bj1270553.
4
Changes in liver tryptophan and tryptophan pyrrolase activity after administration of salicylate and tryptophan to the rat.给大鼠注射水杨酸盐和色氨酸后肝脏色氨酸及色氨酸吡咯酶活性的变化
Biochem Pharmacol. 1972 Jan;21(1):97-101. doi: 10.1016/0006-2952(72)90254-7.
5
A comparison of mouse and rat liver enzymes and their response to treatment with various compounds.
Biochem Pharmacol. 1972 Apr 1;21(7):1025-9. doi: 10.1016/0006-2952(72)90407-8.
6
Effect of chronic intake of ethanol on pyridine nucleotide levels in rat liver and kidney.长期摄入乙醇对大鼠肝脏和肾脏中吡啶核苷酸水平的影响。
Can J Physiol Pharmacol. 1970 Aug;48(8):542-9. doi: 10.1139/y70-082.
7
Feedback control of rat liver tryptophan pyrrolase. I. End product inhibition of trytophan pyrrolase activity.大鼠肝脏色氨酸吡咯酶的反馈控制。I. 色氨酸吡咯酶活性的终产物抑制
J Biol Chem. 1967 Mar 25;242(6):1192-8.
8
The mechanism of inhibition of rat liver tryptophan pyrrolase activity by 4-hydroxypyrazolo(3,4-d)pyrimidine (Allopurinol).4-羟基吡唑并（3,4-d）嘧啶（别嘌呤醇）对大鼠肝脏色氨酸吡咯酶活性的抑制机制。
Biochem J. 1973 Jul;133(3):585-91. doi: 10.1042/bj1330585.