急性和慢性给予尼古丁酒石酸氢（+）盐及其随后撤药对大鼠肝脏色氨酸吡咯酶活性的影响，以及与吗啡、苯巴比妥和乙醇影响的比较。
The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.
作者信息
Badawy A A, Evans M
出版信息
Biochem J. 1975 Jun;148(3):425-32. doi: 10.1042/bj1480425.
Abstract
Acute administration of nicotine hydrogen (+)-tartrate enhances the activity of rat liver tryptophan pyrrolase by a hormonal mechanism. Chronic nicotine treatment inhibits, and subsequent withdrawal enhances, the pyrrolase activity. The inhibition during chronic treatment is not due to a defective apoenzyme synthesis nor a decreased cofactor availability. Regeneration of liver NADP+ in vitro and in vivo reverses the inhibition. Chronic nicotine administration increases the liver NADPH concentration. The above effects of nicotine resemble to a remarkable degree those previously shown for morphine, phenobarbitone and ethanol. All effects are compared, and their possible significance in relation to drug dependence is discussed.
摘要
急性给予（+）-酒石酸氢尼古丁可通过激素机制增强大鼠肝脏色氨酸吡咯酶的活性。长期尼古丁处理会抑制该酶活性，而随后的戒断则会增强其活性。长期处理期间的抑制并非由于脱辅基酶合成缺陷或辅因子可用性降低所致。体外和体内肝脏NADP +的再生可逆转这种抑制作用。长期给予尼古丁会增加肝脏NADPH浓度。尼古丁的上述作用在很大程度上类似于先前对吗啡、苯巴比妥和乙醇所显示的作用。对所有作用进行了比较，并讨论了它们与药物依赖性相关的可能意义。
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