• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

急性和慢性给予尼古丁酒石酸氢（+）盐及其随后撤药对大鼠肝脏色氨酸吡咯酶活性的影响，以及与吗啡、苯巴比妥和乙醇影响的比较。

The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.

作者信息

Badawy A A, Evans M

出版信息

Biochem J. 1975 Jun;148(3):425-32. doi: 10.1042/bj1480425.

DOI:10.1042/bj1480425
PMID:989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1165559/
Abstract

Acute administration of nicotine hydrogen (+)-tartrate enhances the activity of rat liver tryptophan pyrrolase by a hormonal mechanism. Chronic nicotine treatment inhibits, and subsequent withdrawal enhances, the pyrrolase activity. The inhibition during chronic treatment is not due to a defective apoenzyme synthesis nor a decreased cofactor availability. Regeneration of liver NADP+ in vitro and in vivo reverses the inhibition. Chronic nicotine administration increases the liver NADPH concentration. The above effects of nicotine resemble to a remarkable degree those previously shown for morphine, phenobarbitone and ethanol. All effects are compared, and their possible significance in relation to drug dependence is discussed.

摘要

急性给予（+）-酒石酸氢尼古丁可通过激素机制增强大鼠肝脏色氨酸吡咯酶的活性。长期尼古丁处理会抑制该酶活性，而随后的戒断则会增强其活性。长期处理期间的抑制并非由于脱辅基酶合成缺陷或辅因子可用性降低所致。体外和体内肝脏NADP +的再生可逆转这种抑制作用。长期给予尼古丁会增加肝脏NADPH浓度。尼古丁的上述作用在很大程度上类似于先前对吗啡、苯巴比妥和乙醇所显示的作用。对所有作用进行了比较，并讨论了它们与药物依赖性相关的可能意义。

相似文献

1
The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.急性和慢性给予尼古丁酒石酸氢（+）盐及其随后撤药对大鼠肝脏色氨酸吡咯酶活性的影响，以及与吗啡、苯巴比妥和乙醇影响的比较。
Biochem J. 1975 Jun;148(3):425-32. doi: 10.1042/bj1480425.
2
The role of liver tryptophan pyrrolase in the opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on rat brain tryptophan metabolism.肝脏色氨酸吡咯酶在长期给药及随后停用依赖性药物对大鼠脑色氨酸代谢产生的相反作用中的作用。
Biochem J. 1981 Apr 15;196(1):161-70. doi: 10.1042/bj1960161.
3
The effects of chronic phenobarbitone administration and subsequent withdrawal on the activity of rat liver tryptohan pyrrolase and their resemblance to those of ethanol.长期给予苯巴比妥及其撤药后对大鼠肝脏色氨酸吡咯酶活性的影响以及它们与乙醇作用的相似性。
Biochem J. 1973 Nov;135(3):555-7. doi: 10.1042/bj1350555.
4
The effects of ethanol on tryptophan pyrrolase activity and their comparison with those of phenobarbitone and morphine.乙醇对色氨酸吡咯酶活性的影响及其与苯巴比妥和吗啡影响的比较。
Adv Exp Med Biol. 1975;59:229-51. doi: 10.1007/978-1-4757-0632-1_15.
5
The effects of chemical porphyrogens and drugs on the activity of rat liver tryptophan pyrrolase.化学卟啉原和药物对大鼠肝脏色氨酸吡咯酶活性的影响。
Biochem J. 1973 Dec;136(4):885-92. doi: 10.1042/bj1360885.
6
Inhibition of rat brain tryptophan metabolism by ethanol withdrawal and possible involvement of the enhanced liver tryptophan pyrrolase activity.乙醇戒断对大鼠脑色氨酸代谢的抑制作用以及肝脏色氨酸吡咯酶活性增强可能与之有关。
Biochem J. 1980 Nov 15;192(2):449-55. doi: 10.1042/bj1920449.
7
Tryptophan pyrrolase in rat liver after phenobarbital administration.苯巴比妥给药后大鼠肝脏中的色氨酸吡咯酶
Toxicology. 1973 Sep;1(3):179-86. doi: 10.1016/0300-483x(73)90004-8.
8
Guinea-pig liver tryptophan pyrrolase. Absence of detectable apoenzyme activity and of hormonal induction by cortisol and possible regulation by tryptophan.豚鼠肝脏色氨酸吡咯酶。未检测到脱辅基酶活性，不存在皮质醇的激素诱导作用以及色氨酸可能的调节作用。
Biochem J. 1974 Mar;138(3):445-51. doi: 10.1042/bj1380445.
9
Reversal by naloxone of the effects of chronic administration of drugs of dependence on rat liver and brain tryptophan metabolism.纳洛酮对长期给予依赖性药物对大鼠肝脏和脑色氨酸代谢影响的逆转作用。
Br J Pharmacol. 1981 Oct;74(2):489-94. doi: 10.1111/j.1476-5381.1981.tb09995.x.
10
Effects of pyridoxine on hepatic tryptophan pyrrolase activity in rat during chronic ethanol administration.慢性乙醇给药期间吡哆醇对大鼠肝脏色氨酸吡咯酶活性的影响。
Biochem Exp Biol. 1980;16(4):391-6.

引用本文的文献

1
Rapid reversal by naloxone of the chronic effects of morphine on rat liver and brain tryptophan metabolism.纳洛酮对吗啡对大鼠肝脏和脑色氨酸代谢的慢性影响的快速逆转作用。
Br J Pharmacol. 1981 Nov;74(3):511-3. doi: 10.1111/j.1476-5381.1981.tb10457.x.
2
Reversal by naloxone of the effects of chronic administration of drugs of dependence on rat liver and brain tryptophan metabolism.纳洛酮对长期给予依赖性药物对大鼠肝脏和脑色氨酸代谢影响的逆转作用。
Br J Pharmacol. 1981 Oct;74(2):489-94. doi: 10.1111/j.1476-5381.1981.tb09995.x.
3
The role of liver tryptophan pyrrolase in the opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on rat brain tryptophan metabolism.肝脏色氨酸吡咯酶在长期给药及随后停用依赖性药物对大鼠脑色氨酸代谢产生的相反作用中的作用。
Biochem J. 1981 Apr 15;196(1):161-70. doi: 10.1042/bj1960161.
4
The mechanism of the antagonism by naloxone of acute alcohol intoxication.纳洛酮对急性酒精中毒的拮抗机制。
Br J Pharmacol. 1981 Nov;74(3):514-6. doi: 10.1111/j.1476-5381.1981.tb10458.x.
5
Transport of the aromatic amino acids into isolated rat liver cells. Properties of uptake by two distinct systems.芳香族氨基酸向分离的大鼠肝细胞中的转运。两种不同系统摄取的特性。
Biochem J. 1986 Jan 15;233(2):499-506. doi: 10.1042/bj2330499.
6
Quantification of the importance of individual steps in the control of aromatic amino acid metabolism.芳香族氨基酸代谢调控中各个步骤重要性的量化
Biochem J. 1986 Mar 15;234(3):635-47. doi: 10.1042/bj2340635.
7
Animal liver tryptophan pyrrolases: Absence of apoenzyme and of hormonal induction mechanism from species sensitive to tryptophan toxicity.动物肝脏色氨酸吡咯酶：对色氨酸毒性敏感的物种中无脱辅基酶及激素诱导机制。
Biochem J. 1976 Jul 15;158(1):79-88. doi: 10.1042/bj1580079.
8
The regulation of rat liver tryptophan pyrrolase activity by reduced nicotinamide-adenine dinucleotide (phosphate). Experiments with glucose and nicotinamide.还原型烟酰胺腺嘌呤二核苷酸（磷酸）对大鼠肝脏色氨酸吡咯酶活性的调节。葡萄糖和烟酰胺的实验。
Biochem J. 1976 May 15;156(2):381-90. doi: 10.1042/bj1560381.

本文引用的文献

1
The role of catecholamines in the free fatty acid response to cigarette smoking.儿茶酚胺在吸烟引起的游离脂肪酸反应中的作用。
Circulation. 1963 Jul;28:52-7. doi: 10.1161/01.cir.28.1.52.
2
A colorimetric method for estimating the pyridine nucleotide content of small amounts of animal tissue.一种用于估算少量动物组织中吡啶核苷酸含量的比色法。
Nature. 1962 Feb 3;193:454-6. doi: 10.1038/193454a0.
3
A microsomal iron-porphyrin activator of rat liver tryptophan pyrrolase.大鼠肝脏色氨酸吡咯酶的微粒体铁卟啉激活剂。
J Biol Chem. 1961 Jan;236:153-7.
4
Effects of nicotine and tobacco smoke on blood pressure and release of catechol amines from the adrenal glands.尼古丁和烟草烟雾对血压及肾上腺儿茶酚胺释放的影响。
Br J Pharmacol Chemother. 1965 Oct;25(2):515-26. doi: 10.1111/j.1476-5381.1965.tb02069.x.
5
Relative rates of tryptophan pyrrolase degradation following the administration of hydrocortisone and tryptophan to intact and adrenalectomized rat.给完整大鼠和肾上腺切除大鼠注射氢化可的松和色氨酸后色氨酸吡咯酶的相对降解速率。
Biochim Biophys Acta. 1971 Oct;252(1):117-24. doi: 10.1016/0304-4165(71)90099-7.
6
The effects of salicylate on the activity of rat liver tryptophan pyrrolase in vitro and in vivo.水杨酸盐对大鼠肝脏色氨酸吡咯酶体内外活性的影响。
Biochem J. 1971 Jun;123(2):171-4. doi: 10.1042/bj1230171.
7
Changes in liver tryptophan and tryptophan pyrrolase activity after administration of salicylate and tryptophan to the rat.给大鼠注射水杨酸盐和色氨酸后肝脏色氨酸及色氨酸吡咯酶活性的变化
Biochem Pharmacol. 1972 Jan;21(1):97-101. doi: 10.1016/0006-2952(72)90254-7.
8
Tryptophan pyrrolase--a biochemical factor in depressive illness?色氨酸吡咯酶——抑郁症中的一种生化因素？
Br J Psychiatry. 1969 Dec;115(529):1367-74. doi: 10.1192/bjp.115.529.1367.
9
The regulation of tryptophan pyrrolase activity by tryptophan.色氨酸对色氨酸吡咯酶活性的调节作用。
Adv Enzyme Regul. 1966;4:287-97. doi: 10.1016/0065-2571(66)90023-9.
10
Guinea-pig liver tryptophan pyrrolase. Absence of detectable apoenzyme activity and of hormonal induction by cortisol and possible regulation by tryptophan.豚鼠肝脏色氨酸吡咯酶。未检测到脱辅基酶活性，不存在皮质醇的激素诱导作用以及色氨酸可能的调节作用。
Biochem J. 1974 Mar;138(3):445-51. doi: 10.1042/bj1380445.