Robbins L G
Genetics. 1977 Dec;87(4):655-84. doi: 10.1093/genetics/87.4.655.
The meiotic effects of heterozygosity for a deficiency of the zeste-white region of the X chromosome include reduced recombination and increased non-disjunction of the entire chromosome complement. Reduced dosage of a gene or genes in the zeste-white interval, rather than structural heterozygosity, is responsible for the meiotic effect. A model for the recombination effects of reduced enzyme concentration has been developed, and its consequences are comparable with the results obtained for deficiency heterozygosity. Thus, all of the observations can be accounted for by imagining a dosage-sensitive locus in the zeste-white region that codes for an enzyme involved in the recombination process. The interaction of the interchromosomal effect of heterozygous inversions with the deficiency has been examined, and the possibility of using the model for the analysis of other meiotic phenomena is considered.
X染色体上zeste-white区域缺失的杂合性的减数分裂效应包括重组减少和整个染色体组非分离增加。zeste-white区间内一个或多个基因的剂量减少，而非结构杂合性，是造成减数分裂效应的原因。已经建立了一个关于酶浓度降低的重组效应的模型，其结果与缺失杂合性所得到的结果相当。因此，通过设想zeste-white区域中一个对剂量敏感的位点，该位点编码参与重组过程的一种酶，就可以解释所有的观察结果。已经研究了杂合倒位的染色体间效应与缺失的相互作用，并考虑了使用该模型分析其他减数分裂现象的可能性。
