鼠肉瘤病毒诱导的人回复突变细胞的化学转化
Chemical transformation of human revertant cells induced by murine sarcoma virus.
作者信息
Cho H Y, Arnstein P, Rhim J S
出版信息
Int J Cancer. 1978 Jan 15;21(1):22-6. doi: 10.1002/ijc.2910210106.
A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or dimethyl sulfoxide (control). Cells treated only with 3-methylcholanthrene and 7,12-dimethylbenz(alpha)anthracene underwent morphological alteration in vitro, and produced tumors when injected into NIH nude mice. These human revertant cells may be a useful in vitro tool in screening for the potential chemical carcinogens in human cell systems.
一种源自由 Kirsten 小鼠肉瘤病毒诱导的非产生性人骨肉瘤细胞（NP/KHOS）的人回复细胞系，在体外分别用不同水平的多环芳烃（3-甲基胆蒽、7,12-二甲基苯并(α)蒽和苯并(α)芘[BP]）或二甲基亚砜（对照）进行处理。仅用 3-甲基胆蒽和 7,12-二甲基苯并(α)蒽处理的细胞在体外发生形态改变，并且注射到 NIH 裸鼠体内时会产生肿瘤。这些人回复细胞可能是筛选人类细胞系统中潜在化学致癌物的一种有用的体外工具。
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