Transformation of human osteosarcoma cells by a chemical carcinogen.
作者信息
Rhim J S, Kim C M, Arnstein P, Huebner R J, Weisburger E K, Nelson Ress W A
出版信息
J Natl Cancer Inst. 1975 Dec;55(6):1291-4. doi: 10.1093/jnci/55.6.1291.
PMID:813009
Abstract
A human osteosarcoma clonal cell line (TE-85, clone F-5) was treated in vitro with various levels of 7,12-dimethylbenz[a]anthracene or dimethyl sulfoxide (control). Cells treated only with the carcinogen underwent morphologic alteration in vitro, and one of these altered cell lines produced tumors subcutaneously and intracerebrally when injected into NIH nude mice.
摘要
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