浅蓝菌素对粪链球菌大分子合成及细胞分裂的影响。
Effect of cerulenin on Streptococcus faecalis macromolecular synthesis and cell division.
作者信息
Carson D, Daneo-Moore L
出版信息
J Bacteriol. 1978 Feb;133(2):472-6. doi: 10.1128/jb.133.2.472-476.1978.
Abstract
The antibiotic cerulenin has been used to study macromolecular synthesis and cell division in Streptococcus faecalis. The data suggest that lipid and lipoteichoic acid synthesis as well as cell number increase are affected prior to any observable effects on overall mass increase or DNA, RNA, protein, or peptidoglycan synthesis. Treatment with cerulenin of cultures growing at various rates and analysis of the subsequent cell divisions indicate that the antibiotic may block a cell cycle event that precedes the completion of chromosome replication by about 10 min.
摘要
抗生素浅蓝菌素已被用于研究粪肠球菌中的大分子合成和细胞分裂。数据表明，在对总体质量增加或DNA、RNA、蛋白质或肽聚糖合成产生任何可观察到的影响之前，脂质和脂磷壁酸的合成以及细胞数量的增加就已受到影响。用浅蓝菌素处理以不同速率生长的培养物，并对随后的细胞分裂进行分析，结果表明该抗生素可能会阻断一个细胞周期事件，该事件发生在染色体复制完成前约10分钟。
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