Gillis R A, Pearle D L, Hoekman T
Science. 1974 Jul 5;185(4145):70-2. doi: 10.1126/science.185.4145.70.
Cardiac arrhythmias produced by electrical stimulation of the ventrolateral cardiac sympathetic nerve in dogs were not blocked by the combined administration of propranolol and practolol in amounts that completely blocked cardiac beta-adrenergic receptors. Blockade of cardiac alpha-adrenergic receptors, as well as cardiac cholinergic receptors, also had no influence on the arrhythmias. These results suggest that the adrenergic neuroeffector junction is fundamentally different from any hitherto described, differing perhaps in the neurotransmitter involved or in the nature of the receptor.
对犬心脏外侧交感神经进行电刺激所产生的心律失常，在给予能完全阻断心脏β-肾上腺素能受体的普萘洛尔和心得宁联合用药时并未被阻断。阻断心脏α-肾上腺素能受体以及心脏胆碱能受体，对心律失常也没有影响。这些结果表明，肾上腺素能神经效应器接头与迄今所描述的任何接头在根本上都不同，可能在涉及的神经递质或受体性质方面存在差异。
