Cuschieri A, Baker P R
Br J Exp Pathol. 1974 Apr;55(2):110-5.
The diagnostic and prognostic value of serum γ-glutamyl-transpeptidase activity in hepato-biliary disease was investigated in a group of 52 patients. The activity of the enzyme in the serum is elevated in cirrhosis (cryptogenic and alcoholic), chronic active hepatitis, extrahepatic biliary tract obstruction, primary biliary cirrhosis and hepatic neoplasms. In cirrhosis there is a significant decline in serum γ-glutamyl-transpeptidase activity as the condition progresses towards the end stage liver and very low values are found in terminal hepatic coma. In chronic active hepatitis the serum γ-glutamyl-transpeptidase activity is elevated but there is no significant difference between the values during relapse and remission. The serum γ-glutamyl-transpeptidase activity remains elevated for periods of 4-6 weeks after surgical correction of the biliary tract obstruction.
对一组52例患者研究了血清γ-谷氨酰转肽酶活性在肝胆疾病中的诊断和预后价值。肝硬化（隐源性和酒精性）、慢性活动性肝炎、肝外胆道梗阻、原发性胆汁性肝硬化和肝脏肿瘤患者血清中该酶的活性升高。在肝硬化中，随着病情发展至终末期肝病，血清γ-谷氨酰转肽酶活性显著下降，在终末期肝昏迷时发现其值极低。在慢性活动性肝炎中，血清γ-谷氨酰转肽酶活性升高，但复发期和缓解期的值之间无显著差异。胆道梗阻手术矫正后，血清γ-谷氨酰转肽酶活性在4至6周内持续升高。
