Whitfield J B, Pounder R E, Neale G, Moss D W
Gut. 1972 Sep;13(9):702-8. doi: 10.1136/gut.13.9.702.
Serum gamma-glutamyl transpeptidase (GGT) activity correlates closely with the activities of alkaline phosphatase (ALP) and 5'-nucleotidase (5NT) in various forms of liver disease. Maximum elevations of all three enzyme activities are observed in diseases which particularly affect the biliary tract. Compared with the other two enzymes GGT is generally increased to a greater extent and is thus the most sensitive indicator of biliary-tract disease, while estimations of serum GGT are more reproducible than those of 5NT. However, a group of patients who had been treated with phenytoin and barbiturates were found to have elevated serum GGT activities without any other evidence of liver disease. The apparent effect of certain drugs on serum GGT activity indicates the need for caution in interpreting the results of this test.
在各种肝病中，血清γ-谷氨酰转肽酶（GGT）活性与碱性磷酸酶（ALP）和5'-核苷酸酶（5NT）活性密切相关。在特别影响胆道的疾病中，观察到这三种酶活性的最大升高。与其他两种酶相比，GGT通常升高幅度更大，因此是胆道疾病最敏感的指标，而血清GGT的测定比5NT的测定更具可重复性。然而，发现一组接受苯妥英和巴比妥类药物治疗的患者血清GGT活性升高，而无任何其他肝病证据。某些药物对血清GGT活性的明显影响表明，在解释该检测结果时需要谨慎。
