Effect of phenothiazine neuroleptic drugs and tricyclic antidepressants on phosphodiesterase activity in rat cerebral cortex.

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作者信息

Janiec W, Kroczak-Dziuba K, Herman Z S

出版信息

Psychopharmacologia. 1974;37(4):351-8. doi: 10.1007/BF00428921.

DOI:10.1007/BF00428921

PMID:4152850

Abstract

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Effect of phenothiazine neuroleptic drugs and tricyclic antidepressants on phosphodiesterase activity in rat cerebral cortex.

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IS IT POSSIBLE TO PREDICT THE CLINICAL EFFECTS OF NEUROLEPTIC DRUGS (MAJOR TRANQUILLIZERS) FROM ANIMAL DATA?I. "NEUROLEPTIC ACTIVITY SPECTRA" FOR RATS.能否根据动物实验数据预测神经安定药物（主要镇静剂）的临床效果？I. 大鼠的“神经安定活性谱”

Arzneimittelforschung. 1965 Feb;15:104-17.

Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷

J Biol Chem. 1962 Apr;237:1244-50.

The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones.环3',5'-腺苷酸在对儿茶酚胺及其他激素反应中的作用。

Pharmacol Rev. 1966 Mar;18(1):145-61.

Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 1. Structure-activity relationships of agonists and antagonists of biogenic amines and of tricyclic tranquilizers and antidepressants.脑组织孵育切片中环磷酸腺苷的积累。1. 生物胺激动剂和拮抗剂以及三环类镇静剂和抗抑郁药的构效关系。

J Med Chem. 1972 May;15(5):458-62. doi: 10.1021/jm00275a004.

Alpha- and beta-adrenergic receptors as mediators of accumulation of cyclic adenosine 3',5'-monophosphate in specific areas of guinea pig brain.α-和β-肾上腺素能受体作为豚鼠脑特定区域中环磷酸腺苷积累的介质

J Biol Chem. 1971 May 10;246(9):3037-41.

Human brain and platelet cyclic adenosine 3',5'-monophosphate phosphodiesterases: different response to drugs.人脑和血小板环磷腺苷3',5'-单磷酸磷酸二酯酶：对药物的不同反应。

Biochim Biophys Acta. 1972 Aug 18;279(1):217-20. doi: 10.1016/0304-4165(72)90258-9.

Activation and inhibition of lipolysis in isolated fat cells by various inhibitors of cyclic AMP phosphodiesterase.环磷酸腺苷磷酸二酯酶的各种抑制剂对分离脂肪细胞中脂肪分解的激活与抑制作用。

Naunyn Schmiedebergs Arch Pharmacol. 1972;273(1):62-74. doi: 10.1007/BF00508080.

Assay of phosphodiesterase with radioactively labeled cyclic 3',5'-AMP as substrate.以放射性标记的环3',5'-AMP为底物的磷酸二酯酶测定法。

Naunyn Schmiedebergs Arch Pharmakol. 1971;268(3):272-99. doi: 10.1007/BF00997262.

Modification by psychotropic drugs of the cyclic AMP response to norepinephrine in the rat brain in vitro.精神药物对体外培养的大鼠脑中去甲肾上腺素引起的环磷酸腺苷反应的修饰作用。

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