自身致敏淋巴细胞导致氨基甲酸乙酯诱发的肺腺瘤发病率增加。
Increased incidence of urethane induced lung adenomata by autosensitized lymphocytes.
作者信息
Levo Y, Carnaud C, Cohen I R, Trainin N
出版信息
Br J Cancer. 1974 Apr;29(4):312-7. doi: 10.1038/bjc.1974.72.
The present work investigates the influence of autosensitized lymphocytes on the carcinogenic response of the host. Urethane treated SWR mice received 6 fortnightly injections of lymphocytes sensitized in vitro against syngeneic fibroblasts. An increased incidence of lung adenomata was found in these mice compared with controls injected with unsensitized lymphoid cells or with lymphoid cells sensitized against unrelated transplantation antigens. Autosensitized lymphocytes also modified the response of host lymphoid cells to concanavalin A or to stimulation in a mixed lymphocyte culture assay. These results indicate that autoimmune lymphocytes may increase susceptibility of a host to the induction of tumours.
本研究调查了自身致敏淋巴细胞对宿主致癌反应的影响。用氨基甲酸乙酯处理过的SWR小鼠每两周接受6次体外致敏的、针对同基因成纤维细胞的淋巴细胞注射。与注射未致敏淋巴细胞或针对无关移植抗原致敏的淋巴细胞的对照组相比，这些小鼠的肺腺瘤发病率有所增加。自身致敏淋巴细胞还改变了宿主淋巴细胞对刀豆球蛋白A的反应或在混合淋巴细胞培养试验中的刺激反应。这些结果表明，自身免疫淋巴细胞可能会增加宿主对肿瘤诱导的易感性。
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