替代补体途径对几种细菌的调理作用的影响。
Influence of the alternate complement pathway in opsonization of several bacterial species.
作者信息
Forsgren A, Quie P G
出版信息
Infect Immun. 1974 Aug;10(2):402-4. doi: 10.1128/iai.10.2.402-404.1974.
Abstract
In normal human serum chelated with magnesium (10 mM) and ethylene glycotetraacetic acid (10 mM) (MgEGTA), the classical pathway of complement activation is blocked; however, the alternate pathway of complement activation is intact. Diplococcus pneumoniae, Staphylococcus albus, Streptococcus viridans, Streptococcus faecalis, and Serratia marcescens were opsonized in normal human serum containing 10 mM MgEGTA. In contrast, Staphylococcus aureus and Pseudomonas aeruginosa were poorly opsonized in human serum chelated with 10 mM MgEDTA. Therefore certain bacterial species appear to require the classical pathway of complement activation to be opsonized and other bacterial species utilize the alternate pathway of complement activation.
摘要
在与镁（10毫摩尔）和乙二醇四乙酸（10毫摩尔）（MgEGTA）螯合的正常人血清中，补体激活的经典途径被阻断；然而，补体激活的替代途径是完整的。肺炎双球菌、白色葡萄球菌、草绿色链球菌、粪肠球菌和粘质沙雷氏菌在含有10毫摩尔MgEGTA的正常人血清中被调理。相比之下，金黄色葡萄球菌和铜绿假单胞菌在用10毫摩尔MgEDTA螯合的人血清中调理效果不佳。因此，某些细菌种类似乎需要补体激活的经典途径来进行调理，而其他细菌种类则利用补体激活的替代途径。
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