两个近交小鼠亚系中战斗行为与儿茶酚胺生物合成酶活性之间的关联
Association between fighting behavior and catecholamine biosynthetic enzyme activity in two inbred mouse sublines.
作者信息
Ciaranello R D, Lipsky A, Axelrod J
出版信息
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3006-8. doi: 10.1073/pnas.71.8.3006.
Abstract
Levels of three adrenal catecholamine synthesizing enzymes and isolation-induced fighting behavior were studied in two related sublines of the Balb/c inbred mouse strain. Enzyme levels were twice as high in the adrenals of Balb/cJ mice as in those of the Balb/cN mice; heterozygous progeny were intermediate between their parents in the levels of the three enzymes. These sublines also showed marked differences in their fighting behavior after a 2-week isolation period. Balb/cJ mice fought immediately after presentation of an intruder mouse, while Balb/cN mice did not fight at any time during the test. Heterozygous progeny behaved more like the Balb/cN (non-fighters). Analysis of F(2) mice suggested that the differences in fighting behavior were determined by a single gene, with fighting being recessive.
摘要
在近交系Balb/c小鼠品系的两个相关亚系中，研究了三种肾上腺儿茶酚胺合成酶的水平以及隔离诱导的攻击行为。Balb/cJ小鼠肾上腺中的酶水平是Balb/cN小鼠的两倍；杂合子后代在这三种酶的水平上介于其父母之间。在经过2周的隔离期后，这些亚系在攻击行为上也表现出显著差异。引入入侵者小鼠后，Balb/cJ小鼠立即发起攻击，而Balb/cN小鼠在测试期间任何时候都不攻击。杂合子后代的行为更像Balb/cN（非攻击者）。对F(2)代小鼠的分析表明，攻击行为的差异由单个基因决定，攻击行为是隐性的。
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