儿茶酚胺合成相关酶活性的遗传变异。
Genetic variation in activity of enzymes involved in synthesis of catecholamines.
作者信息
Kessler S, Ciaranello R D, Shire J G, Barchas J D
出版信息
Proc Natl Acad Sci U S A. 1972 Sep;69(9):2448-50. doi: 10.1073/pnas.69.9.2448.
Abstract
A genetic analysis of differences in adrenal phenylethanolamine N-methyltransferase (EC 2.1.1.X) and tyrosine hydroxylase (EC 1.99.1.X.) and brain tyrosine hydroxylase was performed in three inbred mouse strains. In adrenal glands, the pattern of inheritance of both enzymes was similar; genes carried by the CBA/J strain appeared to be dominant to those of the other strains. The pattern of inheritance of tyrosine hydroxylase activity in adrenals differed from that in the brain. In both tissues, dominant genes appeared to determine intermediate, rather than extreme, levels of enzyme activities.
摘要
对三种近交系小鼠品系的肾上腺苯乙醇胺N-甲基转移酶（EC 2.1.1.X）、酪氨酸羟化酶（EC 1.99.1.X）以及脑酪氨酸羟化酶的差异进行了遗传学分析。在肾上腺中，这两种酶的遗传模式相似；CBA/J品系携带的基因似乎对其他品系的基因呈显性。肾上腺中酪氨酸羟化酶活性的遗传模式与脑中的不同。在这两种组织中，显性基因似乎决定了酶活性的中等水平，而非极端水平。
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