Todorov T I, Kostov G, Petkov A, Koleva P, Bozhilov B M
Vet Med Nauki. 1977;14(9):10-5.
Obtained were allergens from Brucella abortus 99 and Yersinia enterocolitica Type 9 through hydrolysis with hydrochloric acid after M. M. Ivanov and with acetic acid after Kirzhaev. They were tested on guinea pigs that were infected with Yersinia enterocolitica Type 9 through different ways. To M. M. Ivanov's allergens all infected animals responded pronouncedly in the case of the homologous allergen, and half of them only and to a lower degree in the case of the heterologous Brucella allergen. To Kirzhaev's allergens the infected guinea pigs showed more strongly expressed skin reactions. In this case, too, the response was stronger to the homologous Yersinai allergen. The diameters of skin swelling were more than twice greater than with the use of the heterologous Brucella allergen, and the sum of the reacting skin sites was five times greater in the case of the homologous Yersinia allergen. No essential differences were observed between the oral and the plantar route of infection combined with the subcutaneous injection of carboneum tetrachloratum and the morphine preparation Omnopon.
通过伊万诺夫方法用盐酸水解以及基尔扎耶夫方法用乙酸水解，从流产布鲁氏菌99型和小肠结肠炎耶尔森氏菌9型中获取了变应原。对通过不同方式感染小肠结肠炎耶尔森氏菌9型的豚鼠进行了测试。对于伊万诺夫的变应原，所有感染动物对同源变应原反应明显，而对异源布鲁氏菌变应原，只有一半动物有反应且程度较低。对于基尔扎耶夫的变应原，感染的豚鼠表现出更强的皮肤反应。同样在这种情况下，对同源耶尔森氏菌变应原的反应更强。皮肤肿胀直径比使用异源布鲁氏菌变应原时大两倍多，同源耶尔森氏菌变应原情况下反应皮肤部位的总和大五倍。在口服感染途径与足底感染途径结合皮下注射四氯化碳和吗啡制剂奥姆那庞之间未观察到本质差异。
