[Immunochemical characteristics of pepsinogen-pepsin isoforms from the gastric mucosa of the pig, Sus scrofa].

Electrophoretic and immunoelectrophoretic studies reveal three isoforms of pepsinogen and pepsin which differ in their immunochemical properties. Activation of pepsinogen to pepsin at pH 2 does not affect antigenic properties of the isoforms of the enzyme. Some of the isoforms of commercial pepsin do not exhibit immunogenic properties, although reveal the enzymic activity. This finding indicates that immunochemical and biochemical determinants are located in different parts of isoenzyme molecules.