[人胃黏膜和胃肿瘤中胃蛋白酶原-胃蛋白酶同工型的免疫化学、电泳和酶学分析]
[Immunochemical, electrophoretic and enzymatic analysis of the pepsinogen-pepsin isoforms of human gastric mucosa and gastric tumors].
作者信息
Kalinovskiĭ V P, Belokhvostov A S, Seĭts I F
出版信息
Vopr Onkol. 1978;24(7):41-6.
PMID:354201
Abstract
The obtained specific antiserum against the 1st isoform of pepsinogen of human gastric mucosa responds in immunodiffusion only to the 1st pepsinogen isoform but not to the IId and IIIth one. Human pepsinogen has no common antigenic determinant with pig pepsinogen. The methods of electrophoresis and immunodiffusion reveal the Ist, IId and IIIth isoforms of pepsinogen in human gastric tumors and their metastases, however, they do fail to show any enzymic activity.
摘要
所获得的针对人胃黏膜胃蛋白酶原第1种同工型的特异性抗血清，在免疫扩散中仅对第1种胃蛋白酶原同工型有反应，而对第2种和第3种同工型无反应。人胃蛋白酶原与猪胃蛋白酶原没有共同的抗原决定簇。电泳和免疫扩散方法揭示了人胃肿瘤及其转移灶中胃蛋白酶原的第1种、第2种和第3种同工型，然而，它们确实未显示出任何酶活性。
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