夜间重复服用氯巴占、氯氮䓬二钾和安慰剂对睡眠主观评分、清晨行为以及唤醒、精神运动表现和焦虑的客观测量指标的影响。
The effects of repeated nocturnal doses of clobazam, dipotassium chlorazepate and placebo on subjective ratings of sleep and early morning behaviour and objective measures of arousal, psychomotor performance and anxiety.
作者信息
Hindmarch I, Parrott A C
出版信息
Br J Clin Pharmacol. 1979 Oct;8(4):325-9. doi: 10.1111/j.1365-2125.1979.tb04713.x.
Abstract
- Repeated nocturnal doses of 30 mg clobazam and dipotassium chlorazepate 15 mg showed no significant effects compared to matching placebo on tests of psychomotor performance and serial subtraction of numbers given in the morning and afternoon of the day following treatment. 2. Both active preparations improved the perceived quality of sleep compared to placebo. 3. A reduction in rated anxiety scores was found with clobazam on the afternoon of the day following treatment together with an elevation of critical flicker fusion thresholds. 4. Dipotassium chlorazepate was found to impair performance of a low level conceptual task but not to influence performance at a more difficult level.
摘要
- 与匹配的安慰剂相比，夜间重复服用30毫克氯巴占和15毫克氯氮卓二钾，在治疗后次日上午和下午进行的精神运动性能测试及数字连续减法测试中未显示出显著效果。2. 与安慰剂相比，两种活性制剂均改善了睡眠感知质量。3. 治疗后次日下午，氯巴占使焦虑评分降低，同时临界闪烁融合阈值升高。4. 发现氯氮卓二钾会损害低水平概念任务的表现，但不影响较难水平任务的表现。
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Comparative psychophysiological and mood effects of diazepam and dipotassium clorazepate.
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A 1,4-benzodiazepine, temazepam (K 3917), its effect on some psychological parameters of sleep and behaviour.一种1,4 - 苯二氮䓬类药物，替马西泮（K 3917），其对睡眠和行为的一些心理参数的影响。
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A sub-chronic study of the subjective quality of sleep and psychological measures of performance on the morning following night time medication with temazepam.
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