孕酮对淋病奈瑟菌的影响。
Effect of progesterone on Neisseria gonorrhoeae.
作者信息
Morse S A, Fitzgerald T J
出版信息
Infect Immun. 1974 Dec;10(6):1370-7. doi: 10.1128/iai.10.6.1370-1377.1974.
Abstract
The effects of progesterone on the growth of pathogenic and nonpathogenic species of Neisseria were studied in liquid cultures. Only strains of N. gonorrhoeae and N. meningitidis were highly sensitive to growth inhibition by progesterone. This inhibitory effect was either bacteriostatic or bactericidal, depending upon the ratio of progesterone concentration to cell mass. The site of progesterone inhibition appeared to be located in the cell membrane; >86% of [4-(14)C]progesterone was recovered in the lipid-containing cell fractions. Membrane preparations from N. gonorrhoeae bound progesterone more efficiently than those from progesterone-insensitive cells. In addition, progesterone significantly inhibited the activity of the membrane-associated enzymes reduced nicotinamide adenine dinucleotide oxidase and (cytochrome b) l-lactate dehydrogenase.
摘要
在液体培养中研究了孕酮对淋病奈瑟菌和脑膜炎奈瑟菌致病及非致病菌株生长的影响。只有淋病奈瑟菌和脑膜炎奈瑟菌菌株对孕酮的生长抑制高度敏感。这种抑制作用取决于孕酮浓度与细胞量的比例，可为抑菌或杀菌作用。孕酮抑制的部位似乎位于细胞膜；超过86%的[4-(14)C]孕酮在含脂质的细胞组分中回收。淋病奈瑟菌的膜制剂比孕酮不敏感细胞的膜制剂更有效地结合孕酮。此外，孕酮显著抑制膜相关酶还原型烟酰胺腺嘌呤二核苷酸氧化酶和（细胞色素b）L-乳酸脱氢酶的活性。
相似文献
1
Effect of progesterone on Neisseria gonorrhoeae.孕酮对淋病奈瑟菌的影响。
Infect Immun. 1974 Dec;10(6):1370-7. doi: 10.1128/iai.10.6.1370-1377.1974.
2
Binding of progesterone to Neisseria gonorrhoeae and other gram-negative bacteria.孕酮与淋病奈瑟菌及其他革兰氏阴性菌的结合。
Infect Immun. 1977 Apr;16(1):115-23. doi: 10.1128/iai.16.1.115-123.1977.
3
Inhibitory action of fatty acids on the growth of Neisseria gonorrhoeae.脂肪酸对淋病奈瑟菌生长的抑制作用。
Infect Immun. 1977 Aug;17(2):303-12. doi: 10.1128/iai.17.2.303-312.1977.
4
Isolation and characterization of the outer membrane of Neisseria gonorrhoeae.淋病奈瑟菌外膜的分离与鉴定
J Bacteriol. 1974 Jul;119(1):250-7. doi: 10.1128/jb.119.1.250-257.1974.
5
Neisseria gonorrhoeae possesses two nicotinamide adenine dinucleotide-independent lactate dehydrogenases.淋病奈瑟菌拥有两种不依赖烟酰胺腺嘌呤二核苷酸的乳酸脱氢酶。
FEMS Microbiol Lett. 1994 Jan 1;115(1):39-44. doi: 10.1111/j.1574-6968.1994.tb06611.x.
6
Defenses against oxidative stress in Neisseria gonorrhoeae and Neisseria meningitidis: distinctive systems for different lifestyles.淋病奈瑟菌和脑膜炎奈瑟菌中针对氧化应激的防御机制：不同生活方式的独特系统
J Infect Dis. 2004 Jul 1;190(1):136-47. doi: 10.1086/421299. Epub 2004 Jun 8.
7
Gonococcal cultures.淋球菌培养
JAMA. 1977 Oct 31;238(18):1913-4.
8
Cultivation of Neisseria gonorrhoeae in liquid media and determination of its in vitro susceptibilities to quinolones.淋病奈瑟菌在液体培养基中的培养及其对喹诺酮类药物的体外敏感性测定。
J Clin Microbiol. 2005 Sep;43(9):4321-7. doi: 10.1128/JCM.43.9.4321-4327.2005.
9
Superoxol and amylase inhibition tests for distinguishing gonococcal and nongonococcal cultures growing on selective media.用于区分在选择性培养基上生长的淋球菌和非淋球菌培养物的过氧乙酸和淀粉酶抑制试验。
J Clin Microbiol. 1984 Jul;20(1):1-4. doi: 10.1128/jcm.20.1.1-4.1984.
10
Isolation of a stable cell wall-defective form of Neisseria gonorrhoeae from a case of untreated gonococcal urethritis.
J Clin Microbiol. 1980 Oct;12(4):603-5. doi: 10.1128/jcm.12.4.603-605.1980.
引用本文的文献
1
Metabolism and physiology of pathogenic bacterial obligate intracellular parasites.病原菌专性细胞内寄生菌的代谢和生理学。
Front Cell Infect Microbiol. 2024 Mar 22;14:1284701. doi: 10.3389/fcimb.2024.1284701. eCollection 2024.
2
Sex and Gender Differences in Bacterial Infections.细菌感染中的性别差异。
Infect Immun. 2022 Oct 20;90(10):e0028322. doi: 10.1128/iai.00283-22. Epub 2022 Sep 19.
3
Aging, But Not Sex and Genetic Diversity, Impacts the Pathobiology of Bacterial Endophthalmitis.衰老而非性别和遗传多样性影响细菌性眼内炎的发病机制。
Invest Ophthalmol Vis Sci. 2020 Dec 1;61(14):5. doi: 10.1167/iovs.61.14.5.
4
Selective Inhibition of Coxiella burnetii Replication by the Steroid Hormone Progesterone.孕激素选择性抑制柯克斯体复制。
Infect Immun. 2020 Nov 16;88(12). doi: 10.1128/IAI.00894-19.
5
Role of sex steroid hormones in bacterial-host interactions.性激素在细菌-宿主相互作用中的作用。
Biomed Res Int. 2013;2013:928290. doi: 10.1155/2013/928290. Epub 2012 Dec 24.
6
The relationship between the symptoms of female gonococcal infections and serum progesterone level and the genotypes of Neisseria gonorrhoeae multi-antigen sequence type (NG-MAST) in Wuhan, China.中国武汉女性淋球菌感染症状与血清孕激素水平及淋病奈瑟菌多抗原序列型（NG-MAST）基因型的关系。
Eur J Clin Microbiol Infect Dis. 2011 Jan;30(1):113-6. doi: 10.1007/s10096-010-1040-x. Epub 2010 Sep 4.
7
A gonococcal efflux pump system enhances bacterial survival in a female mouse model of genital tract infection.一种淋球菌外排泵系统可提高细菌在雌性小鼠生殖道感染模型中的存活率。
Infect Immun. 2003 Oct;71(10):5576-82. doi: 10.1128/IAI.71.10.5576-5582.2003.
8
Pathogenesis of pelvic inflammatory disease.盆腔炎的发病机制。
Genitourin Med. 1993 Feb;69(1):9-17. doi: 10.1136/sti.69.1.9.
9
Oxidation of D-lactate and L-lactate by Neisseria meningitidis: purification and cloning of meningococcal D-lactate dehydrogenase.脑膜炎奈瑟菌对D-乳酸和L-乳酸的氧化作用：脑膜炎球菌D-乳酸脱氢酶的纯化与克隆
J Bacteriol. 1993 Oct;175(20):6382-91. doi: 10.1128/jb.175.20.6382-6391.1993.
10
Neisseria gonorrhoeae cell envelope: permeability to hydrophobic molecules.淋病奈瑟菌细胞包膜：对疏水分子的通透性。
J Bacteriol. 1981 Feb;145(2):946-52. doi: 10.1128/jb.145.2.946-952.1981.
本文引用的文献
1
Alterations in dihydropteroate synthetase in cell-free extracts of sulfanilamide-resistant Neisseria meningitidis and Neisseria gonorrhoeae.耐磺胺类药物的脑膜炎奈瑟菌和淋病奈瑟菌无细胞提取物中二氢蝶酸合酶的改变。
Antimicrob Agents Chemother. 1974 Apr;5(4):388-92. doi: 10.1128/AAC.5.4.388.
2
The bactericidal action of beta progesterone.β-孕酮的杀菌作用。
Am J Obstet Gynecol. 1950 Jan;59(1):168-71. doi: 10.1016/0002-9378(50)90362-0.
3
4
RELATIONSHIP OF SURFACTANT PROPERTIES OF SOME SYNTHETIC STEROIDS TO BACTERICIDAL ACTION.
J Pharm Sci. 1964 Oct;53:1214-6. doi: 10.1002/jps.2600531019.
5
NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.淋病奈瑟菌。一、与克隆变异基因连锁的毒力。
J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.
6
7
Steroids and cell surfaces.类固醇与细胞表面。
Biol Rev Camb Philos Soc. 1961 Aug;36:368-98. doi: 10.1111/j.1469-185x.1961.tb01295.x.
8
Steroids. 159. Antimicrobial properties of 21,21-dimethoxy progesterone and other progesterone analogues.类固醇。159. 21,21-二甲氧基孕酮及其他孕酮类似物的抗菌特性。
J Bacteriol. 1961 Mar;81(3):366-75. doi: 10.1128/jb.81.3.366-375.1961.
9
Interference with cellular incorporation of substrates into Staphylococcus aureus by hormones.激素对底物进入金黄色葡萄球菌细胞内过程的干扰。
J Med Microbiol. 1971 Feb;4(1):97-106. doi: 10.1099/00222615-4-1-97.
10
Hormonal intervention in the uptake of amino acids by staphylococci.激素对葡萄球菌摄取氨基酸的干预作用。
J Med Microbiol. 1971 Feb;4(1):89-96. doi: 10.1099/00222615-4-1-89.
Zotero 插件