孕酮对淋病奈瑟菌的影响。
Effect of progesterone on Neisseria gonorrhoeae.
作者信息
Morse S A, Fitzgerald T J
出版信息
Infect Immun. 1974 Dec;10(6):1370-7. doi: 10.1128/iai.10.6.1370-1377.1974.
Abstract
The effects of progesterone on the growth of pathogenic and nonpathogenic species of Neisseria were studied in liquid cultures. Only strains of N. gonorrhoeae and N. meningitidis were highly sensitive to growth inhibition by progesterone. This inhibitory effect was either bacteriostatic or bactericidal, depending upon the ratio of progesterone concentration to cell mass. The site of progesterone inhibition appeared to be located in the cell membrane; >86% of [4-(14)C]progesterone was recovered in the lipid-containing cell fractions. Membrane preparations from N. gonorrhoeae bound progesterone more efficiently than those from progesterone-insensitive cells. In addition, progesterone significantly inhibited the activity of the membrane-associated enzymes reduced nicotinamide adenine dinucleotide oxidase and (cytochrome b) l-lactate dehydrogenase.
摘要
在液体培养中研究了孕酮对淋病奈瑟菌和脑膜炎奈瑟菌致病及非致病菌株生长的影响。只有淋病奈瑟菌和脑膜炎奈瑟菌菌株对孕酮的生长抑制高度敏感。这种抑制作用取决于孕酮浓度与细胞量的比例，可为抑菌或杀菌作用。孕酮抑制的部位似乎位于细胞膜；超过86%的[4-(14)C]孕酮在含脂质的细胞组分中回收。淋病奈瑟菌的膜制剂比孕酮不敏感细胞的膜制剂更有效地结合孕酮。此外，孕酮显著抑制膜相关酶还原型烟酰胺腺嘌呤二核苷酸氧化酶和（细胞色素b）L-乳酸脱氢酶的活性。
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