麦角胺对犬离体股静脉作用方式的研究。
Investigations on the mode of action of ergotamine in the isolated femoral vein of the dog.
作者信息
Müller-Schweinitzer E, Stürmer E
出版信息
Br J Pharmacol. 1974 Jul;51(3):441-6. doi: 10.1111/j.1476-5381.1974.tb10680.x.
Abstract
1 Experiments on spiral strips cut from the femoral vein of dogs suspended in Krebs-Henseleit solution were carried out.2 Ergotamine caused stimulation in concentrations about 350 times lower than noradrenaline (ED(50) of ergotamine = 2.2 x 10(-9) M; ED(50) of noradrenaline = 7.6 x 10(-7) M), but the maximal responses to ergotamine were only about one third those to noradrenaline.3 The pA(2) value of ergotamine against noradrenaline was 8.8.4 The effects of ergotamine can be blocked by prior administration of phentolamine. The pA(2) value for phentolamine against ergotamine was 6.8 and the pA(2) value for phentolamine against noradrenaline was 7.5.5 It is concluded that the stimulant action of ergotamine on smooth vascular muscle probably is mediated mainly via alpha-adrenoceptors.
摘要
对取自狗股静脉、悬浮于克氏-亨氏溶液中的螺旋条进行了实验。
麦角胺引起刺激的浓度比去甲肾上腺素低约350倍（麦角胺的半数有效剂量=2.2×10⁻⁹M；去甲肾上腺素的半数有效剂量=7.6×10⁻⁷M），但麦角胺的最大反应仅约为去甲肾上腺素的三分之一。
麦角胺对去甲肾上腺素的pA₂值为8.8。
预先给予酚妥拉明可阻断麦角胺的作用。酚妥拉明对麦角胺的pA₂值为6.8，酚妥拉明对去甲肾上腺素的pA₂值为7.5。
得出结论：麦角胺对血管平滑肌的刺激作用可能主要通过α-肾上腺素能受体介导。
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