吲哚拉明及其他化合物对神经递质摄取进入大鼠皮层切片的作用。
The action of indoramin and other compounds on the uptake of neurotransmitters into rat cortical slices.
作者信息
Sugden R F
出版信息
Br J Pharmacol. 1974 Jul;51(3):467-9. doi: 10.1111/j.1476-5381.1974.tb10687.x.
Abstract
Indoramin has been tested for its ability to inhibit the uptake of tritiated (-)-noradrenaline and 5-hydroxytryptamine into rat brain cortical slices. Other alpha-blocking agents and tricycic antidepressants were included for comparison. Activity against noradrenaline uptake is probably not important in the therapeutic action of indoramin. However, inhibition of 5-hydroxytryptamine uptake may be responsible for the sedation in high dosage noted by some investigators,
摘要
吲哚拉明已被测试其抑制氚标记的（-）-去甲肾上腺素和5-羟色胺摄取到大鼠脑皮质切片中的能力。还纳入了其他α受体阻滞剂和三环类抗抑郁药进行比较。对去甲肾上腺素摄取的活性在吲哚拉明的治疗作用中可能并不重要。然而，对5-羟色胺摄取的抑制可能是一些研究者所指出的高剂量时镇静作用的原因。
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