5-羟色胺参与苯丙胺作用的证据。
Evidence for involvement of 5-hydroxytryptamine in the actions of amphetamine.
作者信息
Breese G R, Cooper B R, Mueller R A
出版信息
Br J Pharmacol. 1974 Oct;52(2):307-314. doi: 10.1111/j.1476-5381.1974.tb09714.x.
Abstract
1 Pargyline treatment, 1 h before (+)-amphetamine (1 mg/kg), reduced amphetamine-stimulated motor activity. This inhibition was reversed in animals pretreated with p-chlorophenylalanine (PCPA).2 Following treatment with PCPA or 5,6-dihydroxytryptamine (5,6-DHT), amphetamine-induced locomotor activity was significantly potentiated. The increased response to amphetamine in PCPA-treated rats was reversed in animals pretreated with 5-hydroxytryptophan.3 The inhibition of amphetamine-stimulated locomotor activity by treatment with 6-hydroxydopamine was not reversed by PCPA treatment.4 Stereotypies produced by amphetamine were not found to be altered by depletion of 5-hydroxytryptamine.5 Induction of adrenal tyrosine hydroxylase activity produced by chronic amphetamine administration was significantly potentiated by PCPA, emphasizing the involvement of a 5-hydroxytryptamine inhibitory system in more than one action of amphetamine.
摘要
在给予（+）-苯丙胺（1毫克/千克）前1小时用帕吉林治疗，可降低苯丙胺刺激的运动活性。在用对氯苯丙氨酸（PCPA）预处理的动物中，这种抑制作用被逆转。
在用PCPA或5,6-二羟基色胺（5,6-DHT）治疗后，苯丙胺诱导的运动活性显著增强。在用5-羟色氨酸预处理的动物中，PCPA处理的大鼠对苯丙胺增加的反应被逆转。
用6-羟基多巴胺治疗对苯丙胺刺激的运动活性的抑制作用，未被PCPA治疗逆转。
未发现5-羟色胺耗竭会改变苯丙胺产生的刻板行为。
长期给予苯丙胺所诱导的肾上腺酪氨酸羟化酶活性，被PCPA显著增强，这强调了5-羟色胺抑制系统参与苯丙胺的多种作用。
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