Quock R M, Horita A
Pharmacol Biochem Behav. 1976 Dec;5(6):627-31. doi: 10.1016/0091-3057(76)90303-8.
The dopaminergic agonists apomorphine and d-amphetamine elicit hyperthermic, hyperkinetic and stereotypic responses in the rabbit. The present investigation compares the influence exerted by various serotonergic antagonists upon these activities. Apomorphine-induced hyperthemia was antagonized by p-chlorophenylalanine (pCPA), cyproheptadine and cinanserin and was restored in pCPA-pretreated rabbits by regeneration of central serotonin levels, d-Amphetamine-induced hyperthermia was reduced by pCPA; restored in pCPA-pretreated animals by regeneration of central serotonin levels; and was uninfluenced by cyproheptadine and cinanserin. Apomorphine-induced locomotor stimulation was unaltered by serotonergic antagonists; however, these same doses of anti-serotonergic agents all markedly reduced d-amphetamine-induced hyperkinesia. Serotonergic antgaonists also failed to affect apomorphine-induced compulsive gnawing but did significantly enhance d-amphetamine-induced compulsive gnawing. It is concluded from these data that the neuropharmacological activities of apopmorphine and d-amphetamine in the rabbit differ in their dependence upon central serotonergic mechanisms.
多巴胺能激动剂阿扑吗啡和右旋苯丙胺可在兔身上引发体温过高、运动亢进和刻板反应。本研究比较了各种血清素能拮抗剂对这些活动的影响。对氯苯丙氨酸（pCPA）、赛庚啶和辛那色林可拮抗阿扑吗啡诱导的体温过高，且通过恢复中枢血清素水平，可使经pCPA预处理的兔恢复正常；pCPA可降低右旋苯丙胺诱导的体温过高；通过恢复中枢血清素水平，可使经pCPA预处理的动物恢复正常；且赛庚啶和辛那色林对其无影响。血清素能拮抗剂未改变阿扑吗啡诱导的运动刺激；然而，相同剂量的抗血清素剂均显著降低了右旋苯丙胺诱导的运动亢进。血清素能拮抗剂也未影响阿扑吗啡诱导的强迫性啃咬，但显著增强了右旋苯丙胺诱导的强迫性啃咬。从这些数据得出结论，阿扑吗啡和右旋苯丙胺在兔身上的神经药理学活动在对中枢血清素能机制的依赖性方面存在差异。
