心得安与ICI 66082对猫肾神经刺激所致肾素释放作用的阻断效果比较
Comparison of the effects of propranolol and ICI 66082 in blocking the renin releasing effect of renal nerve stimulation in the cat.
作者信息
Johns E J, Singer B
出版信息
Br J Pharmacol. 1974 Oct;52(2):315-8. doi: 10.1111/j.1476-5381.1974.tb09715.x.
Abstract
The comparative effectiveness of propranolol and ICI 66082, in inhibiting the release of renin from the kidney resulting from renal nerve stimulation, has been studied in the cat. Over the dose range 0.17-0.68 x 10(-5) mol/kg propranolol there was a dose-response relationship with the increase of plasma renin activity (PRA) achieved after 10 min stimulation. Over the dose range 0.75-1.69 x 10(-5) mol/kg ICI 66082 also inhibited the release of renin caused by nerve stimulation, but was about five times less effective than propranolol. It would appear from these data that the beta-adrenoceptors within the kidney mediating renin release are distinctly different from those of the heart.
摘要
在猫身上研究了普萘洛尔和ICI 66082在抑制肾神经刺激引起的肾脏肾素释放方面的相对有效性。在0.17 - 0.68×10⁻⁵mol/kg的普萘洛尔剂量范围内，与10分钟刺激后血浆肾素活性（PRA）的增加存在剂量反应关系。在0.75 - 1.69×10⁻⁵mol/kg的ICI 66082剂量范围内，也抑制了神经刺激引起的肾素释放，但效力约为普萘洛尔的五分之一。从这些数据来看，介导肾素释放的肾脏内β-肾上腺素能受体与心脏的明显不同。
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本文引用的文献
1
Effect of catecholamines and the renal nerves on renin secretion in anesthetized dogs.儿茶酚胺和肾神经对麻醉犬肾素分泌的影响。
Am J Physiol. 1965 Sep;209(3):659-62. doi: 10.1152/ajplegacy.1965.209.3.659.
2
Effect of alpha- and beta-adrenergic blocking agents on the increase in renin secretion produced by stimulation of the medulla oblongata in dogs.α-和β-肾上腺素能阻滞剂对刺激犬延髓所引起的肾素分泌增加的影响。
Neuroendocrinology. 1971;7(2):97-104. doi: 10.1159/000121957.
3
Effect of alpha- and beta-adrenergic blocking agents on the increase in renin secretion produced by stimulation of the renal nerves.α-和β-肾上腺素能阻滞剂对刺激肾神经引起的肾素分泌增加的影响。
Neuroendocrinology. 1972;10(3):129-38. doi: 10.1159/000122112.
4
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Clin Sci. 1973 Mar;44(3):291-5. doi: 10.1042/cs0440291.
5
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Circ Res. 1973 Feb;32(2):290-6. doi: 10.1161/01.res.32.2.290.
6
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7
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8
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Endocrinology. 1970 Dec;87(6):1318-22. doi: 10.1210/endo-87-6-1318.
9
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