β1 - 肾上腺素能受体参与异丙肾上腺素诱导大鼠肾切片体外肾素释放的证据。
Evidence for the participation of beta1-adrenoceptors in isoprenaline-induced renin release from rat kidny slices in vitro.
作者信息
Desaulles E, Miesch F, Schwartz J
出版信息
Br J Pharmacol. 1978 Jul;63(3):421-5. doi: 10.1111/j.1476-5381.1978.tb07793.x.
Abstract
- The inhibitory effects were studied of 4 beta-adrenoceptor antagonists against renin release induced by isoprenaline (0.5 mumol/1) in rat kidney slices. Additionally the pA2 values of these 4 drugs were measured against isoprenaline in guinea-pig isolated atria and trachea (against beta1- and beta2-adrenoceptors respectively). 2 When employed at a concentration of 2 mumol/1 propranolol and atenolol significantly inhibited renin release (P less than 0.001 and P less than 0.01) whereas practolol and IPS 339 [t-butyl-amino-3 ol-2 propyl) oximino-9 fluorene] had little effect. 2 A positive correlation was shown between the degree of inhibition of renin release and the pA2 of the antagonists at the beta1-adrenoceptors. 4 When practolol and IPS 339 were used in equipotent molar concentrations to propranolol for the beta1-adrenoceptors they inhibited renin release. 5 The results suggest that the adrenoceptor involved in the renin release induced by isoprenaline in the rat kidney is of the beta1-type.
摘要
- 研究了4种β-肾上腺素能拮抗剂对异丙肾上腺素（0.5微摩尔/升）诱导的大鼠肾切片肾素释放的抑制作用。此外，还在豚鼠离体心房和气管中（分别针对β1-和β2-肾上腺素能受体）测定了这4种药物对异丙肾上腺素的pA2值。2. 当以2微摩尔/升的浓度使用时，普萘洛尔和阿替洛尔显著抑制肾素释放（P<0.001和P<0.01），而醋丁洛尔和IPS 339 [叔丁基氨基-3-（2-丙基）肟基-9-芴]几乎没有作用。2. 肾素释放的抑制程度与拮抗剂在β1-肾上腺素能受体处的pA2之间呈正相关。4. 当醋丁洛尔和IPS 339以与普萘洛尔等摩尔浓度用于β1-肾上腺素能受体时，它们抑制肾素释放。5. 结果表明，异丙肾上腺素诱导大鼠肾释放肾素所涉及的肾上腺素能受体为β1型。
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