Matoi J R, Jeffrey L P
Am J Hosp Pharm. 1978 Feb;35(2):165-8.
The reproduction of phage T7 in the presence of hydroxylamine (HA) (mutagenesis in vivo) results in the phenotypic suppression of some amber mutants. The presence of O-methylhydroxylamine (OMHA) results in a similar effect, including a simlilar mechanism for the action of the two compounds. Since the rate of reaction of mutagen with nucleoside residues under these conditions is negligibly low, one of the most plausible explanations of this effect is the enzymic formation of modified precursors and their incorporation into bacterial tRNAs or phage-induced RNA.
噬菌体T7在羟胺（HA）存在下的繁殖（体内诱变）会导致一些琥珀突变体的表型抑制。O-甲基羟胺（OMHA）的存在也会产生类似的效果，包括这两种化合物作用的类似机制。由于在这些条件下诱变剂与核苷残基的反应速率极低，对此效应最合理的解释之一是修饰前体的酶促形成及其掺入细菌tRNA或噬菌体诱导的RNA中。
