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Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations.

作者信息

Law F C, Eling T E, Bend J R, Fouts J R

出版信息

Drug Metab Dispos. 1974 Sep-Oct;2(5):433-42.

PMID:4156306

Abstract

摘要

相似文献

Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations.

Drug Metab Dispos. 1974 Sep-Oct;2(5):433-42.

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Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung.

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Metabolic oxidation of aliphatic basic nitrogen atoms and their alpha-carbon atoms.

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引用本文的文献

The isolated perfused lung.

Environ Health Perspect. 1984 Jun;56:35-41. doi: 10.1289/ehp.845635.

Pulmonary metabolism of foreign compounds: its role in metabolic activation.

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Effects of CBDP and MEPQ on the toxicity and distribution of [3H]-soman in mice.

Arch Toxicol. 1990;64(8):663-8. doi: 10.1007/BF01974695.

Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung.

Environ Health Perspect. 1976 Aug;16:77-81. doi: 10.1289/ehp.761677.

Effect of oxygen exposure on lung clearance of amines.

Lung. 1978;155(4):287-95. doi: 10.1007/BF02730703.

Relationship between alveolar PO2 and the rate of p-nitroanisole O-demethylation by the cytochrome P-450 pathway in isolated rabbit lungs.

J Clin Invest. 1979 Sep;64(3):770-4. doi: 10.1172/JCI109522.

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Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations.

作者信息

Law F C, Eling T E, Bend J R, Fouts J R

出版信息

Drug Metab Dispos. 1974 Sep-Oct;2(5):433-42.

PMID:4156306

Abstract

摘要

相似文献

Metabolism of xenobiotics by the isolated perfused lung. Comparison with in vitro incubations.

Drug Metab Dispos. 1974 Sep-Oct;2(5):433-42.

Xenobiotic accumulation and metabolism by isolated perfused rabbit lungs.

J Pharmacol Exp Ther. 1973 Sep;186(3):482-97.

Accumulation of amines in the isolated perfused rabbit lung.

J Pharmacol Exp Ther. 1974 May;189(2):456-66.

A comparison of the in vitro metabolism of parathion in the lung and liver of the rabbit.

Toxicol Appl Pharmacol. 1972 Sep;23(1):123-30. doi: 10.1016/0041-008x(72)90211-6.

Rates of phencyclidine metabolism by the isolated perfused lung, lung microsomes, and liver microsomes of rabbits.

Drug Metab Dispos. 1982 Jul-Aug;10(4):361-5.

Increased analgesia and alterations in distribution and metabolism of methadone by desipramine in the rat.

J Pharmacol Exp Ther. 1975 Oct;195(1):94-104.

Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung.

Environ Health Perspect. 1976 Aug;16:77-81. doi: 10.1289/ehp.761677.

Metabolic oxidation of aliphatic basic nitrogen atoms and their alpha-carbon atoms.

Xenobiotica. 1971 Jul-Oct;1(4):365-83. doi: 10.3109/00498257109041503.

Effect of Hg2+ on accumulation and metabolism of chlorpromazine and imipramine in rat lungs.

Drug Metab Dispos. 1984 May-Jun;12(3):376-8.

The effect of acute and chronic methadone treatment on the in vitro N-demethylation of methadone by microsomal enzymes of male and pregnant and nonpregnant female rats.

Arch Int Pharmacodyn Ther. 1973 Oct;205(2):259-66.

引用本文的文献

The isolated perfused lung.

Environ Health Perspect. 1984 Jun;56:35-41. doi: 10.1289/ehp.845635.

Pulmonary metabolism of foreign compounds: its role in metabolic activation.

Environ Health Perspect. 1990 Apr;85:31-41. doi: 10.1289/ehp.85-1568313.

Effects of CBDP and MEPQ on the toxicity and distribution of [3H]-soman in mice.

Arch Toxicol. 1990;64(8):663-8. doi: 10.1007/BF01974695.

Studies on the uptake, metabolism, and release of endogenous and exogenous chemicals by use of the isolated perfused lung.

Environ Health Perspect. 1976 Aug;16:77-81. doi: 10.1289/ehp.761677.

Effect of oxygen exposure on lung clearance of amines.

Lung. 1978;155(4):287-95. doi: 10.1007/BF02730703.

Relationship between alveolar PO2 and the rate of p-nitroanisole O-demethylation by the cytochrome P-450 pathway in isolated rabbit lungs.

J Clin Invest. 1979 Sep;64(3):770-4. doi: 10.1172/JCI109522.

Role of the lung in total body clearance of circulating drugs.

Clin Pharmacokinet. 1979 Sep-Oct;4(5):355-67. doi: 10.2165/00003088-197904050-00002.