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[通过测定血清鸟氨酸氨基甲酰转移酶评估甲状腺功能亢进症中的肝脏病变]

[Evaluation of hepatic lesions in hyperthyroid conditions by means of determination of serum ornithine-carbamyl-transferase].

作者信息

Bonera E, Bertoni P

出版信息

Quad Sclavo Diagn. 1974 Dec;10(4):509-14.

PMID:4156600
Abstract

OCT is a high specific test of liver mythocondrial damage; it increases early in the serum, before any feature of cell necrosis can histologically demonstrated. Serum values of this enzyme have been studied as an index of liver damage in 22 patients with hyperthyroidism lasting for a period of a minimum of two months to a maximum of two years. Other serum enzymes (gamma-GT, pseudocolinesterase, transaminase) have been studied comparatively. Serum OCT behaviour in the cases reported seems to suggest that hyperthyroidism can induce moderate liver functional improvement (not reliable to hemodynamic alterations) only after long time.

摘要

鸟氨酸氨基甲酰转移酶(OCT)是肝脏线粒体损伤的高特异性检测指标;在血清中它升高得较早,早于细胞坏死的任何特征在组织学上得到证实之前。对22例持续时间最短两个月至最长两年的甲状腺功能亢进患者,研究了该酶的血清值作为肝损伤指标。同时对其他血清酶(γ-谷氨酰转移酶、假胆碱酯酶、转氨酶)进行了比较研究。所报道病例中的血清OCT表现似乎表明,甲状腺功能亢进只有在长时间后才会引起中度肝功能改善(对血流动力学改变不可靠)。

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