肝脏再生的激素调控。
Hormonal control of liver regeneration.
作者信息
Thrower S, Ord M G
出版信息
Biochem J. 1974 Nov;144(2):361-9. doi: 10.1042/bj1440361.
Two peaks in cyclic AMP production in rat livers 4 and 12h after partial hepatectomy (MacManus et al., 1972) were confirmed and a third peak established at 22h, which is the peak of DNA synthesis. The increases in cyclic AMP were prevented by beta-adrenergic blocking agents, propranolol and pindolol, without affecting ornithine decarboxylase induction or DNA synthesis. The alpha-blocking agents, phenoxybenzamine and phentolamine, given at the time of partial hepatectomy, delayed the rise in ornithine decarboxylase normally found 4h after operation, but did not affect DNA synthesis. If the alpha-blocking agents were given at 9-12h or 18h, the onset of DNA synthesis was delayed. Phenoxybenzamine did not affect the induction of ornithine decarboxylase in intact rat livers by glucagon or growth hormone, but did inhibit induction by dexamethasone. The induction of ornithine decarboxylase produced by dexamethasone was inhibited by 17alpha-hydroxy-progesterone; this compound also blocked the induction of ornithine decarboxylase in livers of partially hepatectomized rats.
部分肝切除术后4小时和12小时大鼠肝脏中环状AMP生成的两个峰值（MacManus等人，1972年）得到了证实，并且在22小时时确定了第三个峰值，这也是DNA合成的峰值。β-肾上腺素能阻滞剂普萘洛尔和吲哚洛尔可阻止环状AMP的增加，而不影响鸟氨酸脱羧酶的诱导或DNA合成。在部分肝切除时给予α-阻滞剂苯氧苄胺和酚妥拉明，可延迟通常在术后4小时出现的鸟氨酸脱羧酶的升高，但不影响DNA合成。如果在9至12小时或18小时给予α-阻滞剂，则DNA合成的起始会延迟。苯氧苄胺不影响胰高血糖素或生长激素对完整大鼠肝脏中鸟氨酸脱羧酶的诱导，但确实抑制地塞米松的诱导。地塞米松产生的鸟氨酸脱羧酶的诱导被17α-羟基孕酮抑制；该化合物也阻断了部分肝切除大鼠肝脏中鸟氨酸脱羧酶的诱导。
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