Demin N N, Nechaeva G A
Vopr Biokhim Mozga. 1974;9:171-5.
The effect of acetylcholine, norepinephrine, serotonin, GABA and histone preparations on nervous tissue acid ribonuclease activity has been studied. Acetylcholine and serotonin in vitro were found to reduce the leakage of this enzyme out of lysosomes, whereas norepinephrine and histones enhanced it. These agents did not change free acid ribonuclease activity. It is assumed that these neurotransmitters and histones can take part in the regulation of intracellular RNA metabolism in brain tissue by changing the amount of the free acid ribonuclease fraction through affecting lysosome membranes rather than the activity of the free enzyme. GABA changes neither enzyme leakage out of lysosomes nor its activity.
研究了乙酰胆碱、去甲肾上腺素、血清素、γ-氨基丁酸（GABA）和组蛋白制剂对神经组织酸性核糖核酸酶活性的影响。发现乙酰胆碱和血清素在体外可减少该酶从溶酶体中的泄漏，而去甲肾上腺素和组蛋白则增强了这种泄漏。这些药剂并未改变游离酸性核糖核酸酶的活性。据推测，这些神经递质和组蛋白可通过影响溶酶体膜而非游离酶的活性来改变游离酸性核糖核酸酶部分的量，从而参与脑组织中细胞内RNA代谢的调节。GABA既不改变酶从溶酶体中的泄漏，也不改变其活性。
