Nechaeva G A, Shelepina E P
Ukr Biokhim Zh (1978). 1979 Sep-Oct;51(5):455-8.
Norepinephrine GABA, cystein and SH-glutathione evoke a considerable decrease in the activity of alkaline RNase in the postmitochondrial fraction of the rat brain homogenate where the complex of this enzyme with its natural cytoplasmic protein inhibitor is preliminarily disturbed by the addition of pCMB. However these substances have no effect on the activity of alkaline RNase and its cytoplasmic protein inhibitor each taken separately. Evidently, the studied preparations may favour the reduction of the native state of the inactive complex of the enzyme with its inhibitor which was preliminarily disturbed by the pCMB addition.
去甲肾上腺素、γ-氨基丁酸、半胱氨酸和巯基谷胱甘肽可使大鼠脑匀浆线粒体后组分中碱性核糖核酸酶的活性显著降低，在此之前，通过添加对氯汞苯甲酸（pCMB）已初步破坏了该酶与其天然细胞质蛋白抑制剂的复合物。然而，这些物质对单独的碱性核糖核酸酶及其细胞质蛋白抑制剂的活性均无影响。显然，所研究的制剂可能有利于减少该酶与其抑制剂的无活性复合物的天然状态，而这种复合物已因添加pCMB而初步受到破坏。
