[动物胚后发育过程中脑和肝脏中NAD特异性与NADP特异性异柠檬酸脱氢酶活性的变化]
[Changes in the activities of NAD- and NADP-specific isocitrate dehydrogenases in the brain and liver during the postembryonic development of animals].
作者信息
Prokhorova M I, Putilina F E, Eshchenko N D
出版信息
Vopr Biokhim Mozga. 1974;9:211-8.
The activities of NAD- and NADP-specific isocitrate dehydrogenases (ICDH) were investigated in subcellular fractions of rat brain and liver. Animals of different age groups were used: newborn, 10-, 20-, 30-, 40-days old and adult rats. It was shown that NAD-ICDH activity rose sharply in adult brain mitochondria as compared with that of developing animals. The NAD-dependent pathway of isocitrate oxidation predominated in mitochondria of both developing and adult brain. The activity of NADP-ICDH decreased in brain mitochondria and cytoplasm in the course of development. Some changes in the distribution of enzyme activity between subcellular fractions were also found in adult brain. The activity of mitochondrial NADP-ICDH was higher than that of newborn animals.
在大鼠脑和肝脏的亚细胞组分中研究了NAD特异性和NADP特异性异柠檬酸脱氢酶（ICDH）的活性。使用了不同年龄组的动物：新生大鼠、10日龄、20日龄、30日龄、40日龄大鼠和成年大鼠。结果表明，与发育中的动物相比，成年脑线粒体中的NAD-ICDH活性急剧上升。在发育中和成年脑的线粒体中，异柠檬酸氧化的NAD依赖性途径占主导地位。在发育过程中，脑线粒体和细胞质中的NADP-ICDH活性降低。在成年脑中还发现了酶活性在亚细胞组分之间分布的一些变化。线粒体NADP-ICDH的活性高于新生动物。
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