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J Med Chem. 2011 Jan 13;54(1):222-32. doi: 10.1021/jm1011462. Epub 2010 Dec 3.

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Antiherpesviral activity and inhibitory action on cell growth of 5-alkenyl derivatives of 1-beta D-arabinofuranosyluracil.1-β-D-阿拉伯呋喃糖基尿嘧啶的5-烯基衍生物的抗疱疹病毒活性及对细胞生长的抑制作用。
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本文引用的文献

1
Clinical cure of herpes simplex keratitis by 5-iodo-2-deoxyuridine.5-碘-2-脱氧尿苷对单纯疱疹性角膜炎的临床治愈作用
Proc Soc Exp Biol Med. 1962 Feb;109:251-2. doi: 10.3181/00379727-109-27169.
2
IDU therapy of herpes simplex.单纯疱疹的注射吸毒疗法。 （不过从医学常理看，这个表述不太符合常见医学内容，可能原文有误，正常应该是关于单纯疱疹的某种规范治疗方法表述，比如“Intermittent dosing therapy of herpes simplex”之类，单纯“IDU therapy”这样表述容易误解，这里是按照字面翻译）
Arch Ophthalmol. 1962 May;67:583-91. doi: 10.1001/archopht.1962.00960020583012.
3
THE POSSIBLE ROLE OF RECOMBINATION IN THE INFECTION OF COMPETENT BACILLUS SUBTILIS BY BACTERIOPHAGE DEOXYRIBONUCLEIC ACID.重组在噬菌体脱氧核糖核酸感染感受态枯草芽孢杆菌中的可能作用
Virology. 1964 Dec;24:552-62. doi: 10.1016/0042-6822(64)90207-7.
4
THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS.5-三氟甲基-2'-脱氧尿苷在单纯疱疹性角膜炎中的治疗性抗病毒作用。
Science. 1964 Aug 7;145(3632):585-6. doi: 10.1126/science.145.3632.585.
5
CELL CULTURE STUDIES ON ANTIVIRAL AGENTS. I. ACTION OF CYTOSINE ARABINOSIDE AND SOME COMPARISONS WITH 5-IODO-2-DEOXYURIDINE.抗病毒药物的细胞培养研究。I. 阿糖胞苷的作用及与5-碘-2-脱氧尿苷的一些比较。
Proc Soc Exp Biol Med. 1964 Jan;115:69-77. doi: 10.3181/00379727-115-28834.
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Cure of vaccinia infection by 5-iodo-2'-deoxyuridine.5-碘-2'-脱氧尿苷治愈牛痘感染
Virology. 1962 Dec;18:567-9. doi: 10.1016/0042-6822(62)90058-2.
7
Virus-induced acquisition of metabolic function. I. Enzymatic formation of 5-hydroxymethyldeoxycytidylate.病毒诱导的代谢功能获得。I. 5-羟甲基脱氧胞苷酸的酶促形成。
J Biol Chem. 1959 Jun;234(6):1501-6.
8
Immunobiological studies with the virostatics 5-ethyl-2'-deoxyuridine (EDU) and 1-allyl-3,5-diethyl-6-chlorouracil (ACIU).使用病毒抑制剂5-乙基-2'-脱氧尿苷（EDU）和1-烯丙基-3,5-二乙基-6-氯尿嘧啶（ACIU）的免疫生物学研究。
Chemotherapy. 1969;14(3):129-32. doi: 10.1159/000220621.
9
On the chemotherapy of cancer.论癌症的化疗。
Fortschr Arzneimittelforsch. 1965;8:431-507. doi: 10.1007/978-3-0348-7056-6_6.
10
Studies on the phosphorylation of cytosine arabinoside in mammalian cells.哺乳动物细胞中阿糖胞苷磷酸化的研究。
Mol Pharmacol. 1971 Jul;7(4):413-9.

5-羟甲基脱氧尿苷醚衍生物抗病毒活性的细胞培养研究

Cell culture studies on the antiviral activity of ether derivatives of 5-hydroxymethyldeoxyuridine.

作者信息

Meldrum J B, Gupta V S, Saunders J R

出版信息

Antimicrob Agents Chemother. 1974 Oct;6(4):393-6. doi: 10.1128/AAC.6.4.393.

DOI:10.1128/AAC.6.4.393
PMID:4157332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444658/
Abstract

The antiviral activity of several ether derivatives of 5-hydroxymethyldeoxyuridine against the herpesvirus of infectious bovine rhinotracheitis was determined in monolayer cultures of secondary bovine fetal kidney cells. 5-Methoxy-methyldeoxyuridine (OCH(3)UdR) was found to be markedly inhibitory against this virus. Pretreatment of the cells with OCH(3)UdR, simultaneous addition of OCH(3)UdR with virus to the cells, and postinfection treatment with OCH(3)UdR were found to be effective in inhibiting virus-induced cytopathogenic effect. Against this virus, OCH(3)UdR was found to be as potent as 5-iododeoxyuridine and cytosine arabinoside. The alpha-anomer of OCH(3)UdR did not show antiviral activity. Preliminarly toxicity studies indicate that OCH(3)UdR has a very low acute toxicity.

摘要

在牛胎儿肾传代细胞单层培养物中测定了5-羟甲基脱氧尿苷的几种醚衍生物对传染性牛鼻气管炎疱疹病毒的抗病毒活性。发现5-甲氧基甲基脱氧尿苷（OCH(3)UdR）对该病毒有明显的抑制作用。用OCH(3)UdR预处理细胞、将OCH(3)UdR与病毒同时加入细胞以及用OCH(3)UdR进行感染后处理均能有效抑制病毒诱导的细胞病变效应。发现OCH(3)UdR对该病毒的效力与5-碘脱氧尿苷和阿糖胞苷相当。OCH(3)UdR的α-异构体未显示出抗病毒活性。初步毒性研究表明，OCH(3)UdR的急性毒性非常低。