5-羟甲基脱氧尿苷醚衍生物抗病毒活性的细胞培养研究
Cell culture studies on the antiviral activity of ether derivatives of 5-hydroxymethyldeoxyuridine.
作者信息
Meldrum J B, Gupta V S, Saunders J R
出版信息
Antimicrob Agents Chemother. 1974 Oct;6(4):393-6. doi: 10.1128/AAC.6.4.393.
Abstract
The antiviral activity of several ether derivatives of 5-hydroxymethyldeoxyuridine against the herpesvirus of infectious bovine rhinotracheitis was determined in monolayer cultures of secondary bovine fetal kidney cells. 5-Methoxy-methyldeoxyuridine (OCH(3)UdR) was found to be markedly inhibitory against this virus. Pretreatment of the cells with OCH(3)UdR, simultaneous addition of OCH(3)UdR with virus to the cells, and postinfection treatment with OCH(3)UdR were found to be effective in inhibiting virus-induced cytopathogenic effect. Against this virus, OCH(3)UdR was found to be as potent as 5-iododeoxyuridine and cytosine arabinoside. The alpha-anomer of OCH(3)UdR did not show antiviral activity. Preliminarly toxicity studies indicate that OCH(3)UdR has a very low acute toxicity.
摘要
在牛胎儿肾传代细胞单层培养物中测定了5-羟甲基脱氧尿苷的几种醚衍生物对传染性牛鼻气管炎疱疹病毒的抗病毒活性。发现5-甲氧基甲基脱氧尿苷（OCH(3)UdR）对该病毒有明显的抑制作用。用OCH(3)UdR预处理细胞、将OCH(3)UdR与病毒同时加入细胞以及用OCH(3)UdR进行感染后处理均能有效抑制病毒诱导的细胞病变效应。发现OCH(3)UdR对该病毒的效力与5-碘脱氧尿苷和阿糖胞苷相当。OCH(3)UdR的α-异构体未显示出抗病毒活性。初步毒性研究表明，OCH(3)UdR的急性毒性非常低。
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