丙磺舒对青霉素和头孢菌素衍生物脑脊液浓度的影响。
Effect of probenecid on cerebrospinal fluid concentrations of penicillin and cephalosporin derivatives.
作者信息
Dacey R G, Sande M A
出版信息
Antimicrob Agents Chemother. 1974 Oct;6(4):437-41. doi: 10.1128/AAC.6.4.437.
Abstract
Probenecid may elevate the cerebrospinal fluid (CSF) concentration of penicillin G by inhibiting the excretion of organic acids from CSF. We have studied this phenomenon with various penicillin and cephalosporin derivatives. Penicillin concentrations were determined in rabbits under steady-state conditions before and after intravenous probenecid administration. With both low-dose and high-dose probenecid, CSF penicillin levels increased two to three times as did CSF concentration as a percentage of serum level. The same probenecid effect was consistently demonstrated in animals with experimental pneumococcal meningitis. Probenecid likewise increased the CSF concentration of ampicillin, carbenicillin, nafcillin, cephacatrile, and cefazolin. Probenecid may prove useful in certain bacterial infections where high CSF antibiotic levels are necessary.
摘要
丙磺舒可通过抑制有机酸从脑脊液（CSF）中的排泄来提高脑脊液中青霉素G的浓度。我们已用各种青霉素和头孢菌素衍生物研究了这一现象。在静脉注射丙磺舒前后的稳态条件下，测定了家兔体内的青霉素浓度。无论是低剂量还是高剂量的丙磺舒，脑脊液中青霉素水平均增加了两到三倍，脑脊液浓度占血清水平的百分比也同样增加。在患有实验性肺炎球菌脑膜炎的动物中，始终证明了丙磺舒具有相同的作用。丙磺舒同样提高了氨苄西林、羧苄西林、萘夫西林、头孢乙腈和头孢唑林在脑脊液中的浓度。在某些需要高脑脊液抗生素水平的细菌感染中，丙磺舒可能证明是有用的。
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