盐酸大观霉素与普鲁卡因青霉素G水剂治疗单纯性淋病的比较。
Comparison of spectinomycin hydrochloride and aqueous procaine penicillin G in the treatment of uncomplicated gonorrhea.
作者信息
Duanćić A, Fiumara N J, Alpert S, Lee Y H, Tarr P I, Rosner B, McCormack W M
出版信息
Antimicrob Agents Chemother. 1974 Oct;6(4):512-5. doi: 10.1128/AAC.6.4.512.
Men and women with uncomplicated gonorrhea were randomly assigned to receive aqueous procaine penicillin G (2,400,000 U for men; 2,400,000 U daily for 2 days for women) or spectinomycin hydrochloride (2.0 g for men; 4.0 g for women). Among men who returned for post-treatment evaluation within 10 days, treatment failures were noted among 16 (20.3%) of 79 men who received penicillin and 8 (9.5%) of 84 men who received spectinomycin (P < 0.1). Similarly, 6 (13.3%) of 45 women who received penicillin and 3 (6.5%) of 46 women who received spectinomycin had positive endocervical cultures for Neisseria gonorrhoeae at the time of the post-treatment examination (P = not significant).
患有单纯性淋病的男性和女性被随机分配接受普鲁卡因青霉素G水剂（男性240万单位；女性每日240万单位，共2天）或盐酸大观霉素（男性2.0克；女性4.0克）治疗。在10天内返回接受治疗后评估的男性中，接受青霉素治疗的79名男性中有16名（20.3%）治疗失败，接受大观霉素治疗的84名男性中有8名（9.5%）治疗失败（P<0.1）。同样，接受青霉素治疗的45名女性中有6名（13.3%），接受大观霉素治疗的46名女性中有3名（6.5%）在治疗后检查时宫颈内淋病奈瑟菌培养呈阳性（P无统计学意义）。
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