头孢呋辛与青霉素治疗单纯性淋病的比较。
Comparison of cefuroxime and penicillin in the treatment of uncomplicated gonorrhea.
作者信息
Lossick J G, Thompson S E, Smeltzer M P
出版信息
Antimicrob Agents Chemother. 1982 Sep;22(3):409-13. doi: 10.1128/AAC.22.3.409.
Abstract
In a randomized double-blind trial, 216 men and 142 women infected with uncomplicated gonorrhea were treated with either 1.5 g of cefuroxime or 4.8 x 10(6) U of aqueous procaine penicillin G intramuscularly and 1.0 g of probenecid. The cure rates in the treatment groups were 96 and 95%, respectively. Intramuscularly administered cefuroxime was better tolerated than was procaine penicillin. Comparative antibiotic susceptibility studies revealed that cefuroxime and penicillin were about equally active and that both were more active than cefamandole or cefoxitin. Because cefuroxime is not degraded by the action of beta-lactamase enzymes, it has promise as an alternative to spectinomycin in the treatment of penicillinase-producing Neisseria gonorrhoeae infections.
摘要
在一项随机双盲试验中，216名男性和142名感染单纯性淋病的女性接受了治疗，其中一组肌肉注射1.5克头孢呋辛，另一组肌肉注射480万单位普鲁卡因青霉素G并口服1.0克丙磺舒。治疗组的治愈率分别为96%和95%。肌肉注射头孢呋辛的耐受性优于普鲁卡因青霉素。比较抗生素敏感性研究表明，头孢呋辛和青霉素的活性大致相同，且两者均比头孢孟多或头孢西丁更具活性。由于头孢呋辛不会被β-内酰胺酶降解，因此有望成为治疗产青霉素酶淋病奈瑟菌感染时替代壮观霉素的药物。
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本文引用的文献
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Clinical evaluation of cefuroxime.头孢呋辛的临床评价。
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Cefuroxime treatment of patients with lower respiratory and urinary tract infections.头孢呋辛治疗下呼吸道和泌尿系统感染患者。
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Pharmacokinetic and clinical studies on cefuroxime.头孢呋辛的药代动力学和临床研究。
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