Rose D P, Davis T E
Cancer. 1978 Feb;41(2):666-9. doi: 10.1002/1097-0142(197802)41:2<666::aid-cncr2820410234>3.0.co;2-h.
Plasma TSH and thyroxine levels were measured in 74 early breast cancer patients and 53 with advanced disease, 77 patients with cancer arising in other organs and 67 healthy women of similar age. The mean plasma TSH levels were higher in the breast cancer cases than the other two groups; the difference was statistically significant only in those with advanced disease. Twelve percent of the early breast cancer and 15% of the advanced breast cancer patients had elevated plasma TSH concentrations, compared with only 1% of the other cancer patients and 3% of the controls. Four breast cancer patients with plasma TSH levels above 85 microIU/ml had subnormal plasma thyroxine levels. Five of 29 (17%) early breast cancer patients had excessive plasma TSH responses to TRH.
对74例早期乳腺癌患者、53例晚期乳腺癌患者、77例其他器官癌症患者以及67名年龄相仿的健康女性测定了血浆促甲状腺激素（TSH）和甲状腺素水平。乳腺癌患者的血浆TSH平均水平高于其他两组；仅在晚期乳腺癌患者中，这种差异具有统计学意义。早期乳腺癌患者中有12%、晚期乳腺癌患者中有15%的血浆TSH浓度升高，相比之下，其他癌症患者中仅有1%，对照组中仅有3%出现这种情况。4例血浆TSH水平高于85微国际单位/毫升的乳腺癌患者血浆甲状腺素水平低于正常。29例（17%）早期乳腺癌患者中有5例对促甲状腺激素释放激素（TRH）的血浆TSH反应过度。
