Alter W A, Hawkins R N, Evans D E
Circulation. 1978 Apr;57(4):756-62. doi: 10.1161/01.cir.57.4.756.
Etiology of the negative chronotropic response to coronary artery occlusion was studied in chloralose-anesthetized monkeys. One-minute occlusion of the circumflex (CIRC) coronary artery resulted in marked negative chronotropic responses and consistent alterations in atrial electrograms. These responses were dependent on interruption of flow to a small proximal CIRC branch, and postmortem examination revealed that it perfused the sinus node region. The negative chronotropic response was not dependent on any apparent neural reflexes because it was not affected by autonomic blockade. Coronary artery occlusion in anesthetized monkeys can result in significant decreases in heart rate and changes in atrial electrical activity when flow to the pacemaker region is interrupted. We suggest that (1) rhesus monkeys may be suitable for study of the sick sinus syndrome, and (2) atropine-resistant bradycardia and atrial arrhythmias observed in postinfarction patients may be due to sinus node artery blockade.
在水合氯醛麻醉的猴子中研究了冠状动脉闭塞致负性变时反应的病因。左旋支（CIRC）冠状动脉闭塞1分钟导致明显的负性变时反应以及心房电图的持续改变。这些反应取决于一小段近端CIRC分支血流的中断，尸检显示该分支为窦房结区域供血。负性变时反应不依赖于任何明显的神经反射，因为它不受自主神经阻滞的影响。当起搏区域血流中断时，麻醉猴子的冠状动脉闭塞可导致心率显著下降和心房电活动改变。我们认为：（1）恒河猴可能适合用于病态窦房结综合征的研究；（2）心肌梗死后患者中观察到的阿托品抵抗性心动过缓和房性心律失常可能是由于窦房结动脉阻塞所致。
