正常人类新生儿体内的抗I抗体。
Anti-I antibody in normal human newborn infants.
作者信息
Adinolfi M
出版信息
Immunology. 1965 Jul;9(1):43-52.
A cold agglutinin with anti-I specificity is present in a high percentage of cord sera. Evidence is produced that this antibody, like the `naturally-occurring' anti-I present in adult serum, is not a γG-globulin; thus the antibody, both in cord serum and in adult serum, is inactivated by treatment with 2-mercaptoethanol, is not eluted with γG-globulin using DEAE-cellulose chromatography and is recovered in the fast sedimenting fractions after ultracentrifugation. Furthermore, the antibody does not disappear from the circulation of newborn infants as do γG antibodies which cross the human placenta. These findings indicate that the antibody in cord serum is a γM-globulin and that its production often begins before birth.
高比例的脐血血清中存在具有抗I特异性的冷凝集素。有证据表明，这种抗体与成人血清中存在的“天然”抗I一样，不是γG球蛋白；因此，脐血血清和成人血清中的抗体在用2-巯基乙醇处理后会失活，使用DEAE-纤维素色谱法不能用γG球蛋白洗脱，并且在超速离心后会在快速沉降组分中回收。此外，这种抗体不会像穿过人胎盘的γG抗体那样从新生儿的循环中消失。这些发现表明，脐血血清中的抗体是γM球蛋白，其产生通常在出生前就开始了。
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