新生儿的吞噬作用、调理作用及免疫球蛋白研究。
Phagocytic, opsonic and immunoglobulin studies in newborns.
作者信息
Miller M E, Stiehm E R
出版信息
Calif Med. 1973 Aug;119(2):43-63.
Despite improved diagnositc and therapeutic measures, neonatal septicemia continues to be a major clinical problem. Improvement in the management of the septic neonate should result from application of the increasing information being learned of the neonatal host defense mechanisms. The earlier concept that the neonate was "immunologically null" can now be discarded. Evidence summarized in this review has established that the neonate can marshal an immune response to most antigens and infectious agents.A further major advance in recent years has been in understanding of the inflammatory response in the neonate, which includes such activities as chemotaxis, phagocytosis and bactericidal killing of ingested bacteria by phagocytes.
尽管诊断和治疗措施有所改进，但新生儿败血症仍然是一个主要的临床问题。对败血症新生儿管理的改善应源于对新生儿宿主防御机制不断增加的认识的应用。新生儿“免疫功能缺失”这一早期概念现在可以摒弃了。本综述总结的证据表明，新生儿能够对大多数抗原和感染因子产生免疫反应。近年来的另一项重大进展是对新生儿炎症反应的理解，这包括趋化作用、吞噬作用以及吞噬细胞对摄入细菌的杀菌作用等活动。
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