203例神经系统疾病患者的血清和脑脊液免疫球蛋白M

Serum and cerebrospinal fluid IGM in 203 neurological patients.

作者信息

Schuller E, Delasnerie N, Hélary M, Lefèvre M

出版信息

Eur Neurol. 1978;17(2):77-82. doi: 10.1159/000114927.

Abstract

Simultaneous serum and CSF IgM determinations were made by electroimmunodiffusion in 5 normals and 203 patients. Absent from normal CSF, IgM was found in 56 patients (27%): (1) A blood-CSF transudation was present in 25 patients (12%). IgM seems of no diagnostic value in these cases. (2) A purely local synthesis was demonstrated in 17 patients (8%), concerning proved (bacterial, viral, parasitic) or supposed (multiple sclerosis) persistent infectious aggressions. (3) In the last 14 patients with IgM in CSF, a transudation was associated with a local synthesis of IgG (meningitis pattern). (4) A ratio IgM .10(3)/albumin above 10 seems an argument for multiple sclerosis.

摘要

对5名正常人和203名患者采用电免疫扩散法同时测定血清和脑脊液中的IgM。正常脑脊液中不存在IgM，但在56名患者（27%）中检测到：（1）25名患者（12%）存在血脑积液渗漏。在这些病例中，IgM似乎没有诊断价值。（2）在17名患者（8%）中证实存在单纯局部合成，涉及已证实的（细菌、病毒、寄生虫）或推测的（多发性硬化症）持续性感染侵袭。（3）在最后14名脑脊液中存在IgM的患者中，渗漏与IgG的局部合成相关（脑膜炎模式）。（4）脑脊液中IgM.10(3)/白蛋白比值高于10似乎支持多发性硬化症的诊断。