Local synthesis of CSF immunoglobulins. A neuroimmunological classification.

The relationship between serum and CSF IgG has been analysed: (1) In patients with a normal CSF concentration of albumin, no correlation can be demonstrated between serum IgG and CSF IgG. (2) In cases where the CSF albumin concentration is elevated (i.e. transudation), local synthesis of IgG can be determined by reference of the degree of transudation of albumin and the serum IgG concentration. The combination of local IgG synthesis and transudation (meningitic pattern) is common. Most pure transudates are of "non-inflammatory" type. A very simple formula is proposed which evaluates the relationship between local and general immunity in all neurological diseases.