Factor S M, Winn R M, Biempica L
Hum Pathol. 1978 Jan;9(1):114-20. doi: 10.1016/s0046-8177(78)80013-6.
A recent case of myeloma kidney disease was studied to determine the cellular origin of the syncytial multinucleated giant cell. Light, immunofluorescence, and electron microscopy of the giant cells revealed features characteristic of histiocytes. This finding contradicts the generally accepted conclusion that the giant cell represents a syncytial mass of degenerating or reactive tubular epithelial cells. We conclude that the giant cells arise in the interstitial tissues, migrate through breaks in the tubular basement membrane, and engulf and surround intratubular protein casts.
最近对一例骨髓瘤肾病病例进行了研究，以确定多核巨细胞的细胞起源。对这些巨细胞进行光镜、免疫荧光和电镜观察，发现其具有组织细胞的特征。这一发现与普遍接受的结论相矛盾，即巨细胞代表变性或反应性肾小管上皮细胞的融合团块。我们得出结论，巨细胞起源于间质组织，通过肾小管基底膜的破损处迁移，吞噬并包绕肾小管内的蛋白管型。
