Sessa A, Torri Tarelli L, Meroni M, Ferrario G, Giordano F, Volpi A
Appl Pathol. 1984;2(4):185-94.
The origin of multinucleated giant cells in myeloma kidney is not yet defined. These cells have long been thought to represent tubular epithelial cells transformed in syncytia, but, more recently, they have been considered as histiocytic cells arising from the interstitial tissue. We have studied by electron microscopy the distal tubules of kidney biopsies of 5 patients affected with myeloma kidney: our ultrastructural findings do not seem to clarify the problem. In fact, in the same patient, we have observed multinucleated giant cells probably originating from epithelial tubular cells and others, probably originating from histiocytes.
骨髓瘤肾病中多核巨细胞的起源尚未明确。长期以来，这些细胞一直被认为代表着融合成多核的肾小管上皮细胞，但最近，它们被认为是源自间质组织的组织细胞。我们通过电子显微镜研究了5例骨髓瘤肾病患者肾脏活检的远端肾小管：我们的超微结构研究结果似乎并未阐明这一问题。事实上，在同一患者中，我们观察到了可能源自肾小管上皮细胞的多核巨细胞以及其他可能源自组织细胞的多核巨细胞。
