头孢菌素衍生物的免疫原性及其与青霉素的交叉反应。
The immunogenicity of cephalosporin derivatives and their cross-reaction with penicillin.
作者信息
Batchelor F R, Dewdney J M, Weston R D, Wheeler A W
出版信息
Immunology. 1966 Jan;10(1):21-33.
Abstract
Cephalothin and cephaloridine, antibiotics with the 7-amino cephalosporanic acid nucleus, have been shown to form protein conjugates which were able to stimulate production of haemagglutinating, precipitating and guinea-pig skin-sensitizing antibodies in the rabbit. A high degree of cross-reaction with the benzyl penicilloyl determinant group was demonstrated, but evidence was found of only very limited cross-reaction with the haptenic determinant of the penicillin nucleus, 6-amino penicillanic acid. Cephalothin did not induce contact sensitivity in guinea-pigs. These results are discussed with particular respect to the relative parts which the side chain and nucleus of these related antibiotics play in determining antigenic specificity.
摘要
头孢噻吩和头孢噻啶是具有7-氨基头孢烷酸核的抗生素，已被证明能形成蛋白质结合物，这些结合物能够刺激兔子产生血凝、沉淀和豚鼠皮肤致敏抗体。已证明与苄青霉素酰决定簇基团有高度交叉反应，但仅发现与青霉素核的半抗原决定簇6-氨基青霉烷酸有非常有限的交叉反应证据。头孢噻吩不会在豚鼠中诱发接触性过敏。针对这些相关抗生素的侧链和核在决定抗原特异性中所起的相对作用，对这些结果进行了讨论。
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