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1
The formation of antigenic polymers in aqueous solutions of -lactam antibiotics.β-内酰胺抗生素水溶液中抗原聚合物的形成。
Immunology. 1971 Sep;21(3):517-25.
2
A comparison of the amounts and the antigenicity of polymeric materials formed in aqueous solution by some beta-lactam antibiotics.一些β-内酰胺抗生素在水溶液中形成的聚合材料的量和抗原性的比较。
Immunology. 1971 Sep;21(3):527-33.
3
The immunogenicity of cephalosporin derivatives and their cross-reaction with penicillin.头孢菌素衍生物的免疫原性及其与青霉素的交叉反应。
Immunology. 1966 Jan;10(1):21-33.
4
Antigens in penicillin allergy. I. A radioimmunoassay for detection of penicilloylated protein contaminants in penicillin preparations.青霉素过敏中的抗原。I. 一种用于检测青霉素制剂中青霉素酰化蛋白质污染物的放射免疫分析法。
Int Arch Allergy Appl Immunol. 1977;55(1-6):13-22.
5
[The influence of penicillinase on hapten inhibitions in vitro and in vivo in experimental penicillin allergy].[青霉素酶对实验性青霉素过敏中体外和体内半抗原抑制的影响]
Z Immunitatsforsch Exp Klin Immunol. 1971;141(3):265-73.
6
Antibody production to low molecular drugs in experimental animals and in man.实验动物和人类中针对低分子药物的抗体产生。
Jpn J Exp Med. 1969 Feb;39(1):21-34.
7
Electrophoretic and antigenic analysis of mouse and guinea pig anaphylactic antibodies.小鼠和豚鼠过敏抗体的电泳及抗原分析。
J Immunol. 1972 Apr;108(4):1055-62.
8
Antigenic properties of polymers formed by beta-lactam antibiotics.由β-内酰胺抗生素形成的聚合物的抗原特性。
Int Arch Allergy Appl Immunol. 1976;50(2):192-205. doi: 10.1159/000231496.
9
The role of penicilloylated protein impurities, penicillin polymers and dimers in penicillin allergy.
Int Arch Allergy Appl Immunol. 1968;33(6):535-67. doi: 10.1159/000230070.
10
Characterization and properties of an anaphylactic 7S antibody in sheep.绵羊中一种过敏反应性7S抗体的特性与性质
J Immunol. 1974 Feb;112(2):722-7.

引用本文的文献

1
Chromatography of penicillins, penicilloates, and penicilloylamides on dextran gels.青霉素、青霉素酸盐和青霉素酰酰胺在葡聚糖凝胶上的色谱分析
Antimicrob Agents Chemother. 1974 Jun;5(6):617-29. doi: 10.1128/AAC.5.6.617.
2
The ampicillin rash. Lymphocyte transformation by ampicillin polymer.氨苄西林皮疹。氨苄西林聚合物引起的淋巴细胞转化。
Clin Exp Immunol. 1974 Dec;18(4):553-64.
3
Penicillin allergy.青霉素过敏
Clin Rev Allergy. 1986 May;4(2):171-88. doi: 10.1007/BF02991107.
4
IgM and IgG antibody levels to ampicillin in patients with infectious mononucleosis.传染性单核细胞增多症患者针对氨苄西林的IgM和IgG抗体水平。
Clin Exp Immunol. 1976 Nov;26(2):214-21.
5
Editorial: Ampicillin rashes.社论：氨苄西林皮疹
Br Med J. 1975 Jun 28;2(5973):708-9.

本文引用的文献

1
STUDIES IN HUMAN PENICILLIN ALLERGY: A COMPARISON OF VARIOUS PENICILLOYL-POLYLYSINES.
J Lab Clin Med. 1963 Sep;62:482-91.
2
Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction.抗体 - 抗原相互作用引发的实验动物皮肤即时反应。
Prog Allergy. 1958;5:459-508.
3
Degradation kinetics of 6-aminopenicillanic acid.6-氨基青霉烷酸的降解动力学
J Pharm Sci. 1967 Oct;56(10):1273-6. doi: 10.1002/jps.2600561011.
4
Some aspects of penicillin allergy.青霉素过敏的某些方面。
Proc R Soc Med. 1968 Sep;61(9):897-9. doi: 10.1177/003591576806100918.
5
The role of penicilloylated protein impurities, penicillin polymers and dimers in penicillin allergy.
Int Arch Allergy Appl Immunol. 1968;33(6):535-67. doi: 10.1159/000230070.
6
Penicilloylated protein contaminating 6-amino-penicillanic acid and benzylpenicillin.污染6-氨基青霉烷酸和苄青霉素的青霉素酰化蛋白。
Antimicrob Agents Chemother (Bethesda). 1967;7:553-9.
7
Reduction in immunological manifestations of 6-aminopenicillanic acid by treatment with water-insoluble pronase.用水不溶性链霉蛋白酶治疗降低6-氨基青霉烷酸的免疫表现。
Eur J Biochem. 1970 Jul;14(3):509-15. doi: 10.1111/j.1432-1033.1970.tb00317.x.
8
Laboratory and pharmacological studies in man with hetacillin and ampicillin.在人体中使用缩酮氨苄青霉素和氨苄青霉素的实验室及药理学研究。
Br Med J. 1967 Jun 24;2(5555):804-8. doi: 10.1136/bmj.2.5555.804.
9
An immunologic study of selected penicillin reactions involving the skin.一项关于涉及皮肤的特定青霉素反应的免疫学研究。
Arch Dermatol. 1968 May;97(5):503-19.
10
Reduction in incidence of ampicillin rash by purification of ampicillin.通过氨苄西林纯化降低氨苄西林皮疹的发生率。
Br Med J. 1970 Feb 21;1(5694):469-71. doi: 10.1136/bmj.1.5694.469.

β-内酰胺抗生素水溶液中抗原聚合物的形成。

The formation of antigenic polymers in aqueous solutions of -lactam antibiotics.

作者信息

Dewdney J M, Smith H, Wheeler A W

出版信息

Immunology. 1971 Sep;21(3):517-25.

PMID:4105474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1408158/
Abstract

Samples from concentrated aqueous solutions of β-lactam antibiotics were examined by gel filtration. The eluates were monitored by ultraviolet (uv) absorption and by passive cutaneous anaphylaxis (PCA) in guinea-pigs sensitized with appropriate antiserum raised in rabbits. The appearance of uv absorbing material, giving a positive PCA reaction, in fractions from the high molecular weight regions of the eluates from gel filtration of aged solutions was taken as evidence of antigenic polymer formation.

摘要

采用凝胶过滤法对β-内酰胺类抗生素浓水溶液的样本进行检测。用在兔体内产生的相应抗血清致敏豚鼠，通过紫外线（uv）吸收和被动皮肤过敏反应（PCA）对洗脱液进行监测。在老化溶液凝胶过滤洗脱液的高分子量区域的组分中，出现具有阳性PCA反应的紫外线吸收物质，被视为抗原性聚合物形成的证据。