β-内酰胺抗生素水溶液中抗原聚合物的形成。
The formation of antigenic polymers in aqueous solutions of -lactam antibiotics.
作者信息
Dewdney J M, Smith H, Wheeler A W
出版信息
Immunology. 1971 Sep;21(3):517-25.
Abstract
Samples from concentrated aqueous solutions of β-lactam antibiotics were examined by gel filtration. The eluates were monitored by ultraviolet (uv) absorption and by passive cutaneous anaphylaxis (PCA) in guinea-pigs sensitized with appropriate antiserum raised in rabbits. The appearance of uv absorbing material, giving a positive PCA reaction, in fractions from the high molecular weight regions of the eluates from gel filtration of aged solutions was taken as evidence of antigenic polymer formation.
摘要
采用凝胶过滤法对β-内酰胺类抗生素浓水溶液的样本进行检测。用在兔体内产生的相应抗血清致敏豚鼠，通过紫外线（uv）吸收和被动皮肤过敏反应（PCA）对洗脱液进行监测。在老化溶液凝胶过滤洗脱液的高分子量区域的组分中，出现具有阳性PCA反应的紫外线吸收物质，被视为抗原性聚合物形成的证据。
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本文引用的文献
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STUDIES IN HUMAN PENICILLIN ALLERGY: A COMPARISON OF VARIOUS PENICILLOYL-POLYLYSINES.
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Some aspects of penicillin allergy.青霉素过敏的某些方面。
Proc R Soc Med. 1968 Sep;61(9):897-9. doi: 10.1177/003591576806100918.
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6
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Antimicrob Agents Chemother (Bethesda). 1967;7:553-9.
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Eur J Biochem. 1970 Jul;14(3):509-15. doi: 10.1111/j.1432-1033.1970.tb00317.x.
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Laboratory and pharmacological studies in man with hetacillin and ampicillin.在人体中使用缩酮氨苄青霉素和氨苄青霉素的实验室及药理学研究。
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